Title: Thyroid Profile among the Subjects from Fluorotic Zone – A Biochemical Perspective
Authors: Jwalaram Kumar Chaluvadi, Vijay Kumar Kutala, Viswa Kumar Ramalinga, Vijay Kumar J, Chandra Mohan Vadlamudi
DOI: https://dx.doi.org/10.18535/jmscr/v7i3.191
Abstract
Study aimed at assessing the thyroid function under the influence of high fluoride content in the water in fluorosis prevalent zones. In addition to bone and teeth soft tissue like thyroid gland were also shown to be affected as evident from the earlier studies. Fluoride can rapidly cross cell membrane in tissues that are metabolically active and hence the thyroid gland. Fluoride also interferes with Thyroid Stimulating Hormone (TSH) production and also the thyroid hormones free Triiodothyronine (FT3) and free Thyroxine (FT4). Prakasam district in Andhra Pradesh is fluorosis prone zone and subjects visiting Government medical institution from these areas are chosen as subjects and blood samples were collected to study parameters of thyroid function tests [FT3, FT4 and TSH]. Fluoride levels of the water from the fluorotic zones and also in the serum of the subjects were estimated for the correlative study. Altered thyroid function was evident with low FT3, FT4 levels and high TSH levels. Concurrently high levels of fluoride were seen in the water samples from the concerned areas, the subjects hailing from. The results were statistically significant reflecting hypothyroid status in majority of the subjects in association with fluorosis as evident by high levels of fluoride in the water.
Keywords: Fluorosis, Thyroid Concentration, Thyroid Function tests, Hypothyroidism.
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