Title: Malignant Fibrous Histiocytoma of the Breast: A Rare Case Report
Authors: Pattanayak Lucy, Panda Niharika, Padhi Sanjukta, Devi Padmalaya, Samantaray Sagarika
DOI: http://dx.doi.org/10.18535/jmscr/v3i8.02
DIDS : 08.2015-41567279
Background: Primary malignancies of the breast stromal elements and sarcomas of mesenchymal elements constitute less than 1 % of all breast neoplasms and malignant fibrous histiocytoma (MFH) of the breast is exceptionally rare. Histopathologically it is characterized by tumor pleomorphism with varying proportion of fibroblast and histiocyte like cells which stain positive for vimentin. We report our experience of a young female with MFH of the breast treated with mastectomy and adjuvant chemotherapy. Case: A 27 years old female presented with a progressively increasing lump in her right breast. On examination the lump was in the upper outer quadrant of the right breast,8 X 8cm in size, firm, mobile and nontender. The overlying skin was tense and glossy; neck or axillary nodes were not palpable. FNAC showed round to spindle shaped cells arranged in clusters; trucut biopsy revealed the cells in a typical storiform pattern suggestive of MFH.A mastectomy was done and patient received 3 cycles of adjuvant chemotherapy. 2 months after completion of chemotherapy she was asymptomatic. Conclusion: MFH of the breast is an extremely uncommon entity and a complete clinicopathological correlation with histopathological profile is requisite to arrive at an accurate diagnosis. The present case stresses upon the fact that MFH of breast must be kept as a differential diagnosis of any breast lump showing spindle cells and pleomorphism on cytology. Key Words: MFH, breast, tumor pleomorphism 1. Tavassoli FA (editor): Mesenchymal lesions. In: Pathology of the Breast. Second Edition. New York, Elsevier Science Publishing, 1992 pp 539-563. 2. Tamir G Nobel M, Hauben DJ, Sandbank J. Malignant fibrous histiocytoma of the breast. Eur J of Surgical Oncol 1995; 21: 210-11 3. Ozello L, Stout AP, Murray MR. Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer 1963; 16: 331-334. 4. Enzinger FM and Weiss SW: Soft tissue tumors ed 2 . St Louis: CV Mosby, 1988 5. Freter C. Other cancers of the breast. In: Harris JR,Lippman ME, Morrow M, Osborne CK,editors, Diseases of the breast. 2nd ed.Lippincott Williams and Wilkins: Philadelphia; 1999.p685. 6. Sheppard DG and Li bshitz HI: Post radiation sarcomas: a review of the clinical and imaging features in 63 cases. Clin Radiol 56: 22-29, 2001. 7. Mason RW, Einspanier GR and Caleel RT: Radiation induced sarcoma of the breast. J Am Osteopath assoc 96:368-370, 1996. 8. Ajisaka H,Maeda K,Uchiyama A,Miwa A. Myxoid malignant fibrous histiocytoma of the breast.Surg Today 2002; 32:887-890. 9. Sigurd Lunde, Jahn M.Nesland, Ruth Holm and Jan Vincents Johannessen. Primary malignant histiocytoma of the breast. Histol Histopath (1986)1:27-32 10. Singh K, Singh K, Singh A.Rajan, Singh G, Singh R: Primary malignant fibrous histiocytoma of the breast. Indian J Surg 2007; 69:28-32. 11. Langharn M.R., Mills A.S., Demay R.M., O’Dowd G.J., Grathwohl M.A. and Horsley J.S.111 (19840.Malignant fibrous histiocytoma of the breast. A case report and review of the literature. Cancer 54,558-563. 12. Iellin A, Waizbard E, Levine T, Behar A. Malignant fibrous histiocytoma of the breast. Int Surg 1990; 75:63-66.Abstract
References