Title: Plasminogen Activator Inhibitor Type 1 in Patients with Alcoholic Liver Cirrhosis Associated with Non-alcoholic Fatty Liver Disease
Authors: Virstiuk Nataliia Hryhorivna, Matkovska Nataliia Romanivna
The aim of the work was to study the changes of PAI-1 in patients with alcoholic liver cirrhosis (ALC) associated with non-alcoholic fatty liver disease (NAFLD), depending on the decompensation of the disease.
Material and Methods: 80 patients with ALC: 72 men and 8 women, aged 34 to 65 years were examined. Among them there were 38 patients with ALC (Group I) and 42 patients with ALC in combination with non-alcoholic fatty liver disease (NAFLD).
Results: An increase of PAI-1 content in the blood was found in patients with ALC, which increased with more pronounced decompensation of cirrhosis from A to B and C Child-Pugh Classes. The rate of PAI-1 was higher in a combination of ALC and NAFLD at all stages of the liver cirrhosis decompensation. The adverse effect of PAI-1 on the course of the ALC in combination with NAFLD according to correlation with the Child-Pugh score and the MELD index was revealed. We also interrelated the increasing content of PAI-1 in the blood of patients with ALC with concomitant NAFLD with indicators of immunoinflammatory system process (high-sensitivity C-reactive protein, tumour necrosis factor alpha), insulin resistance (immunoreactive insulin, HOMA-IR index) adipocytokines (leptin, adiponectin) endothelial dysfunction (asymmetric dimethylarinin).
Conclusion: Basing on the data of the study, it should be concluded that an increase in the content of PAI-1 adversely affects the course of the ALC with concomitant NAFLD, which substantiates the expediency of its use as a prognostic marker for such a cohort of patients.
Keywords: alcoholic liver cirrhosis, non-alcoholic fatty liver disease, plasminogen activator inhibitor type 1, decompensation, adipocytokines, endothelial dysfunction.