Title: Study of Thyroid hormone (T3, T4, TSH) level in dialyzed Chronic Kidney Disease (CKD) Patients
Authors: Dr Nitesh Singhal, Dr Ajay Kumar Bhargava, Dr Sushma Pandey
Objective: This study was undertaken to investigate the effect of renal function, on the thyroid hormone (T3, T4 and TSH) level in dialyzed chronic kidney disease (CKD) patients in both sex and different age group.
Background: Present study designed to analyze the thyroid hormone level in dialyzed CKD patients. Chronic kidney disease (CKD) is associated with a higher prevalence of primary hypothyroidism. The prevalence of chronic kidney disease in India is 17.2% and its association with hypothyroidism. Chronic kidney disease causes uremia which affects peripheral metabolism and hypothalamus-pituitary-thyroid axis. Due to this effect there is disturbance in synthesis and secretion of adequate amount of T3 and T4.
Methods: Thyroid hormone was estimated and levels of thyroid hormone were studied in 50 chronic kidney disease patients verses 50 healthy controls. Serum T3, T4 and TSH was done by chemiluminiscence immunoassay technique (CLIA) on fully auto analyzer (Maglumi1000).
Results: We found both T3 and T4 were significantly reduced (p<0.0001) whereas TSH (p<0.0001) were significantly higher in patient group compared to healthy subjects.
Conclusion: In present study, we demonstrate that renal impairment may lead to thyroid hormone dysfunction. Thyroid function test is important in diagnosis, prognosis and medical management of Chronic Kidney Disease (CKD).
Keywords: Chronic kidney disease (CKD), Thyroid profile (T3, T4, TSH).