Title: Effect of intravenous dexmedetomidine and midazolam on spinal anaesthesia with 0.5% hyperbaric bupivacaine in TURP
Authors: Dr Khageswar Raut, Dr Debasish Swain, Dr Sidharth Sraban Routray
Aim: The study was done to evaluate the effects of intravenous administration of dexmedetomidine and midazolam on spinal anaesthesia with 0.5% hyperbaric bupivacaine in transurethral resection of prostate (TURP).
Methods: 75 patients of ASA grade I and II posted for elective transurethral resection of prostate surgeries were included in the study and randomly allocated into three groups. All three groups received 3ml of intrathecal 0.5% bupivacaine heavy, followed by infusion of study drug. Group D received intravenous dexmedetomidine 0.5mcg/kg over 10 min, Group M received infusion of Midazolam and Group NS received infusion of same volume of normal saline as placebo. Duration of analgesia, time to 1st analgesia request, VAS score, hemodynamics and side effects were recorded and analyzed.
Results: The prolongation in duration of analgesia in dexmedetomidine group was statistically significant in comparison to other groups. Time to 1st analgesia request was delayed in group D compared to other groups which was statistically significant. hemodynamic stability was well maintained in dexmedetomidine group.
Conclusion: Intravenous dexmedetomidine is not only prolong the duration of spinal analgesia but also maintain hemodynamic stability in TURP surgery.
Keywords: dexmedetomidine, spinal anaesthesia, hyperbaric bupivacaine, TURP.