Title: Columnar Cell Lesions in patients with Invasive Breast Carcinoma and their correlation with clinico-pathological characteristics.
Authors: Dr Roopal Rathi, MBBS, MD, Dr Nita Khurana, MBBS, MD, Dr T. Singh, MBBS, MD, FRCP, Dr P.N. Agrawal, MBBS, MS
Columnar cell lesions (CCL) are hypothesised as earliest pre invasive lesions of Breast cancer due to similarities with DCIS and Carcinoma. Many of the morphologic and genetic studies describe their association with low-grade carcinomas. Prevalence of CCL was studied in 37 Indian patients with Invasive Breast Carcinoma who did not receive neo-adjuvant chemotherapy with aid of 4 additional sections within 2cm of tumor edges were taken. CCL’s were identified and classified in 26 cases (70.27%). Columnar Cell Change (CCC) were present in 13, Columnar Cell Hyperplasia (CCH) in 11, CCC with atypia in 9, CCH with atypia and CCH with atypia and complex architecture were present in 2cases each. Distribution was extensive in 8.1%, multifocal 32.4%, and focal 29.7% cases. These findings were correlated with various known parameters assessed by chi-square and fischer’s exact test. These included patient age, menopausal status tumor size lymph node status, tumor grade, necrosis, emboli, adipose tissue infiltration, tumor lymphocytic infiltrate, margins, stage. It was concluded that CCL’s do-not correlate with any clinico-pathologic parameter and thus, are not helpful in determining prognosis of patients.