Title: The Correlation between anti Mullerian Hormone with Progesterone / Estradiol Ratio on the day of HCG Administration in IVF Patients at Aster Fertility Clinic Hasan Sadikin Hospital Bandung
Authors: Arief Solehudin, Mulyanusa Ritonga, Wiryawan Permadi, Tono Djuwantono
Objective: To investigate the correlation between AMH with progesterone / estradiol ratio on the day of HCG administration in IVF patients.
Study design: Retrospective study including 43 women undergoing the GnRH antagonist protocol at the Aster Fertility Clinic Hasan Sadikin Hospital Bandung. Normal AMH is > 1.2 ng/ml. Premature luteinisation is defined as progesterone/estradiol ratio > 1 on the day of HCG administration and the sample is divided into premature lutenization if ratio > 1 and control if ratio < 1. Groups were correlated using Spearman.
Results: Of the 43 patients, mean AMH normal without PL is 4,1±3,3 ng/ml, and AMH with PL is 1,9±1,9 ng/ml. Control patients with P / E2 <1 ratio were 39 patients (91%), and patients with luteinized premature with a P / E2> 1 ratio were 4 (9%). The mean age in patients with premature luteinization was 37 ± 5 years and control patients was 35 ± 4 years. In this study, there was a moderate, significant, and negative correlation between AMH with progesterone / estradiol ratio on the day of HCG administration (correlation coefficient = - 0,407 with p = 0,007).
Conclusion: The correlation between AMH with progesterone / estradiol ratio on the day of HCG administration in IVF patients is a moderate, significant, and negatif. Further research is needed regarding the function of cytokines and hormonal follicles that are reflected by AMH levels against premature luteinization
Keywords: premature luteinization, AMH, progesterone / estradiol ratio.