Title: Extra pyramidal symptoms between patients consuming typical and atypical anti-psychotics-in tertiary care centre, in eastern India
Authors: Mihir Ranjan Nayak, Manaswini Dash, Debjani Das, Debasish Biswal
Introduction: The introduction of second-generation antipsychotics, with atypical mechanism of action, especially lower dopamine receptors affinity, has met with great expectations among clinicians regarding their potentially lower propensity to cause extrapyramidal syndrome. Numerous studies have examined the incidence and severity of extrapyramidal syndrome with first- and second-generation antipsychotics.
Material and Methods: 100 patients with any psychotic symptoms were taken up in this study. Extra pyramidal symptoms were assessed after taking antipsychotics by applying by –extra-pyramidal side effects scale, Barnes akathisia scale and abnormal involuntary moments scale at the interval of 1 week,2 months, 3 months, 6 months, 9 months & 1 year.
Results: At the end of 1 year treatment based on Extrapyramidal side effects scale that of Bradykinesia –rigidity, observed rigidity, gait and posture, reported tremor, observed tremor, BARS,AIMS scores are more in patients receiving typical antipsychotics than atypical antipsychotics
Interpretation and Conclusion: EPS are more in patients receiving typical antipsychotics than atypical antipsychotics.
Keywords: Anti-Psychotics,extra pyramidal symptoms, comparison.