Title: Safety and Effective Management of Type-2 Diabetes Mellitus Patients by using Sitagliptin
Authors: Chandana.T, Allahuddin.Syed
Objectives: To study the safety and efficacy of the newer oral hypoglycemic agent sitagliptin in management of type-2 diabetes mellitus patients
Methods: This concurrent observational study was carried out in general medicine department of Rajiv Gandhi Institute Of Medical Sciences for a period of 6 months in which type 2 diabetes mellitus patients were recruited based on inclusion and exclusion criteria and were followed to evaluate the efficacy and safety of sitagliptin. Data was analyzed by using graph pad prism-student T-test.
Results: In our study we have recruited 41 patients who met our study criteria of which we categorized based on age and laboratory data, the majority of patients in the age group between 56-65 years (n=14, 34.15%), the RBS was reduced to Comparatively values of RBS, FBS, PPBS, HbA1C were reduced in follow up than base line value. RBS was reduced from 195.5 mg/dl to 155.68 mg/dl. FBS was 167.43 mg/dl at the base line, and then decreased to 135.21 mg/dl after follow-up. Likewise PPBS and HbA1C at base line were 196.6 mg/dl and 6.78 % respectively. Both were decreased to 157 mg/dl and 6.04 % respectively.
Conclusion: Based on results we can conclude that sitagliptin use was not associated with any risks and is effective in management of Type 2 diabetics, treatment with sitagliptin provided clinically meaningful reductions in HbA1C, RBS, FBS, PPBS by using this study we know that gliptins are much more safe and effective in the treatment of type 2 diabetes mellitus.
Keywords: Diabetes mellitus; Sitagliptin; Insulin.