Title: Determinants of Outcome in Convulsive Status Epilepticus in Adults: An Ambispective Study
Authors: Dr I. D. Chaurasia, Dr Prateek Malpani, Dr Neeraj Mane, Dr Vijay Nandmer, Dr M. C. Songara
Background: Ours is an ambispective observational study conducted in the Department of Neurosurgery attached to Gandhi Medical College, Bhopal.
The patients of convulsive SE (cSE), i.e., prolonged or intermittent seizures lasting beyond 5 minutes, without full recovery of sensorium, are admitted to our well equipped (NICU) and treated consecutively as per the departmental cSE treatment protocol adopted and modified from ILAE.
Study Designed: Ambispective Observational study
Result: Although the STESS score of >2 was found to be associated with higher odds of poor outcome (OR- 2.52, CI- 0.75-8.4, Table 1). With 55.8% of the patients with STESS>2 getting discharged and 23.9% of those with a score of ≤2 experiencing poor outcome, its ability to identify the unfavorable outcome correctly was poor (AUC 0.62, sensitivity of 75% and specificity of 45.7%).
Conclusion: In conclusion, our study identifies that low MAP, delay of >3.5h in treatment initiation or seizure control are the determinants of poor outcome in cSE. With incorporation of CSEOS, we believe that our findings can be helpful in the process of clinical decision making and prognostication of patients with cSE
Keywords: Outcome, Convulsive, Epilepticus & Adults.