Title: A Case of Hypothyroidism with Anti-dsDNA Negative Lupus Nephritis Presenting as Pericardial Effusion: A Diagnostic Dilemma
Authors: Viral Sangwan, Dr Lakshmi Priya Dr Surender Dr Richa Aggarwal
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that may involve many different organs and display a variable clinical course. From a pathogenetic point of view, the production of several autoantibodies characterizes the disease. The diagnosis of SLE is based on characteristic clinical findings of the skin, joints, kidneys, and the central nervous system, as well as on serological parameters such as antinuclear antibodies (ANA), in particular, antibodies to dsDNA. Here we present the case of a 30-year-old female patient, known case of hypothyroidism, who presented with polyserositis and renal involvement and upon investigations was diagnosed to be a case of Anti-ds DNA negative lupus nephritis.