Title: Clinical Profile of Acute Pancreatitis in Magadh Region of Bihar, India

Authors: Rajiv Ranjan, A K Jha, K. K. Sinha

 DOI: https://dx.doi.org/10.18535/jmscr/v6i12.30

Abstract

Background: Acute pancreatitis remains a disorder with devasting consequences. Although most episodes are mild and self-limiting, up to one fifth of patient develop a severe attack that can be fatal. In spite of technical advances in medical and surgical field’s acute pancreatitis remains a major cause of morbidity and mortality. So this challenging subject is taken up for the present study in which we will be studying age, sex prevalence and etiology and clinical presentation of acute pancreatitis. This study was a prospective observational hospital based study performed after the hospital’s ethical clearance. This study was undertaken during mid 2016 and mid 2018 at of Anugrah Narayan Magadh Medical College and Hospital, Gaya, Magadh Division of Bihar, India.  40 consecutive acute pancreatitis cases were analysed.

Objectives: To study the age, sex prevalence and etiological factors of acute pancreatitis.

Material & Methods: The study population consisted of 40 cases of acute pancreatitis that fulfilled the diagnostic criteria. Data collection on admission included age, sex, address and clinical presentation with respect to pain vomiting, gallstones trauma and drugs was noted. History of precious episodes and co- morbidities were noted. Chi-square tests were employed to find out the difference between groups of

frequencies obtained for the specific statements.

Conclusion: Out of 40 patients, Males were (55%) and (45%) were females. Majority of patients were belonging to the age group of 41-60 (42.5%) with a median age of 37 yrs. Most common etiology for acute pancreatitis was biliary (55%) followed by alcoholism (32.5%), hyperlipidemia (2.5%) and traumatic (2.5%) pancreatitis was found in one patient each and where no cause was found was labelled as idiopathic (7.5%). Biliary pancreatitis was the cause of acute pancreatitis in Females 88.3%. In males, alcoholism induced pancreatitis (50%) was most common, second commonest was biliary etiology.

Keywords: Acute pancreatitis, Alcohol, Traumatic pancreatitis, Biliary panceatitis, Gall stones.

References

  1. Steinberg WM, Goldstein SS, Davis ND, Shamma'a J, Anderson K. Diagnostic Assays in Acute PancreatitisA Study of Sensitivity and Specificity. Annals of internal medicine. 1985 May 1;102(5):576-80.
  2. Baily and love’s short practice ofsurgery, 26th edition, chapter 68,pancreatitis, page no 1127.
  3. Neoptolemos JP, Kemppainen EA, Mayer JM,et al. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. Lancet 2000; 355:1955-1960.
  4. Chen CC, Wang SS, Lee FY, et al. Proinfl amatory cytokines in early assessment of the prognosis of acute pancreatitis. Am J Gastroenterol 1999; 94:213-218.
  5. Beger HG, Rau BM. Severe acutepancreatitis: Clinical course and World J Gastroenterol,2007; 13: 5043-51.
  6. Buchler MW, Gloor B, Muller CA,Friess H, Seiler CA, Uhl W. Acutenecrotizing pancreatitis: TreatmentStrategy According to the status of Annals of Surgery, 2000; 232:619-26.,4=Santvoort HCV, Bakker OJ, Bollen TL,Besselink MG, Ali UA, Schrijver AM. AConservative and minimally invasiveapproach to necrotizing pancreatitisimproves outcome. Gastroentrology,2011; 141: 1254-63.
  7. Vlodov J, Tenner S.Acute and chronic pancreatitis. Prim Care 2001; 28:607-28.
  8. Maingot’s abdominal operations, 12th edition, chapter 54, page no 1098.
  9. Balthazar EJ. Acute pancreatitis:Assess-ment of severity with clinical andCT evaluation. Radiology, 2002; 223:603-13
  10. Glenn F, Frey C. Re-evaluation of the treatment of pancreatitis associated with biliary tract disease,Ann Surg. 1964;160:723-36.
  11. K. Pannu, A. Saroch, N. Sharma. (2017) Cullen’s sign & acute pancreatitis. QJM: An International Journal of Medicine110:5, 315-315. 
  12. Werner J, Hartwig W, Uhl W, Müller C, Büchler MW. Useful markers for predicting severity and monitoring progression of acute pancreatitis. Pancreatology. 2003:3(2):115-27.

Corresponding Author

Rajiv Ranjan

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.