Title: Aqueous extract of Cynodon dactylon may be an effective option with reduced risk of side effect for the treatment of Diabetes Mellitus
Authors: Dr Md Shadab Alam, Dr Mukesh Chandra Das, Dr Amrendra Narayan Mishra, Dr Arun Kumar Choudhary, Dr Satish Chandra
Though different types of oral hypoglycaemic drugs are available along with insulin for the treatment of type-2 Diabetes Mellitus, but they have significant side effects and sometimes they are found to be ineffective in chronic diabetic patients. Thus, there is an increasing demand of natural products with high antidiabetic potential and lesser side effects. Among these aqueous extract of Cynodon dactylon (Doob Grass) has been used as an antidiabetic agent in traditional system of medicine in India. The aim of this study is to investigate the antidiabetic effect of aqueous extract of Cynodon dactylon in streptozotocin induced diabetic albino rats. For this purpose, experimental rats were divided into three groups: Group A, B and C namely; normal control, diabetic control and diabetic rat treated with aqueous extract of cynodon dactylon (500 mg/kg body wt.) respectively. Animals were subjected to induce diabetes by intraperitoneal injection of a single dose of 50 mg/kg body weight of streptozotocin. Animals with moderate hyperglycemia, i.e. serum glucose between 200-350mg/dl were taken into consideration for administration of aqueous extract of Cynodon dactylon. The whole experiment was performed for a period of 28 days. Our result concludes that aqueous extract of cynodon dactylon is able to reduce the fasting blood sugar in diabetic rats, and that the rate of fall of FBS was more in 3rd week of study while later in 4th week it achieves almost to normal range.
Keywords: Antidiabetic effect, aqueous extract, Cynodon Dactylon, Streptozotocin induced diabetic rats.