Title: Evaluation of Wound Healing Activity of Leaves of bombax Ceiba
Authors: Dr Amit Kumar, Dr Salman Shamim
Bombax Ceiba, commonly known as Silk cotton tree, is used in folklore medicine in Diabetics, Hypertension, as analgesics, leucorrhoea, sealing of secondary infection, healing of wounds and skin eruptions. There was no scientific evidence justifying the use of Leaves of Bombax Ceiba, therefore the present study was aimed at evaluation of wound healing activity of the plant. In the present study the leaves of Bombax ceiba were studied for wound healing activity by incorporating extract in simple ointment base B.P. in concentration of 2% (w/w) and 5% (w/w) .Wound healing activity was studied in two types of model in rats viz. excision and incision wound model. The results were also comparable to those of a standard drug, Povidone Iodine in terms of wound contracting ability, wound closure time, tensile strength. The statistical data indicated that the wound with ointment containing 5% w/w Methanolic extract exhibited significant (P < 0.001) wound contracting ability and period of epithelization. Significant tensile strength was observed with both the ointment formulations 2% w/w and 5% w/w. Excision wound models was supported by histopathological examination. The experimental data demonstrated that Bombax Ceiba displayed significant wound healingactivity.