Title: Role of lipoprotein (A) as a Nonconventional Risk Factor in Patients of Acute Myocardial Infarction in Tertiary Centre of North India
Authors: Dr Ram Asre, Dr Mridul Chaturvedi, Dr Balvir Singh, Dr Kushal Pal
Objective: The study the levels of liporotein (a) as a nonconventional risk factor in patients with acute myocardial infarction.
Methods: The present study was conducted in the P.G. Dept. of Medicine in the Cardiology Unit, S.N. Medical College, Agra. Patients of any age group willing to take part in the study. Patients who meets the criteria for diagnosing acute myocardial infarction. Determination of Lp(a) levels was done by Immunoturbidimetric test. This test has measuring range from 3-150 mg/dl.
Results: Clinical outcome was judged by mortality at the end of 24 hours, 48 hours and 1 week and a total of 38% of patients succumbed to their illness by the end of the above period. Highest mortality was seen within 24 hours period. Higher LpA values (>20mg/dl)were present in 68.42% of expired patients.63.64% of the patients with mortality within 24 hours had high Lp (a) values while amongst those who died within 48 hours and 1 week, 75% and 75% had high values respectively. There was significant difference in the mean LpA values of patients within 24 hours (T values = 2.183, p value = 0.002) and within 24-48 hours (t values = 1.771, p value = 0.004), 48 hours to 7 days (t value = 1.630, p value = 0.003).
Conclusion: In the search of non-conventional risk factor to explain the present CAD epidemic in north Indian population. Lp(a) is important non-conventional risk factor however other non-conventional risk factors like Apo A1, A2, fibrinogen level are also need to be investigated and explain CAD burden in north Indian population.
Keywords: Lipoprotein (a), acute MI, nonconventional risk factor.