Title: Fractional excretion of urea and fractional excretion of sodium in differentiation of the acute kidney injury in eastern state of Jharkhand, Ranchi, India
Authors: Dr Jitendra Kumar Naik, Dr Arun Kumar Mahato, Dr Rajendra Kumar Jha
Background: Acute kidney injury is the sudden impairment of kidney function, resulting in the retention of urea and other nitrogenous waste products normally cleared by the kidney. Main objective of the present study is to compare the fractional excretion of urea (FEUrea) and fractional excretion of sodium (FENa) in differential diagnosis of Acute Kidney Injury.
Research Design: Clinical observation and experimental design were done for the purpose of present study.
Method: We are selected in participants for the present study, these consecutive randomly admitted patients in the department of medicine in Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Sample: Total 75 Patients were selected in the present study.
Result: Finding of the present study fractional excretion of sodium (FENa) ROC curve (0.957), standard error (0.039), 95% of confidence interval (0.835 to 0.995) and the level of significant in p-value (0.5) is 0.0001; fractional excretion of urea (FEUrea) ROC curve is 0.976, standard error (0.028), 95% of confidence interval (0.865 to 0.995) and the level of significant in p value (0.5) is 0.0001.
Conclusion: Finding of the result concluded that the FEUrea showed higher sensitivity and specificity in differentiating prerenal from intrinsic AKI in patients irrespective of diuretic exposure.
Keywords: Fraction Excretion of Sodium, Fraction Excretion of Urea, Acute Kidney Injury.