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Category: Volume 06 Issue 11 November 2018
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Title: Diagnostic Performance of Hepcidin in Evaluation of Iron Status among Pregnant Women in Rivers State, Nigeria

Authors: Beauty Echonwere, Teddy C. Adias, Evelyn M. Eze

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i11.45

Abstract

“Iron indices are useful in assessing the state of haemoglobin function and determination of state and degree of anaemia”.  “In humans, aside iron indices are the role of hepcidin in up and down regulation of iron metabolism in normal state and diverse state including pregnancy”. We did evaluate gestational changes in serum hepcidin and iron status among pregnant women”. We evaluated serum hepcidin, ferritin, soluble transferrin receptor, serum iron, unsaturated iron binding capacity, total iron binding capacity at 12, 20, and 30 weeks of gestation in a longitudinal study of 428 apparently healthy women who consisted of 328 pregnant women and 100 non-pregnant who served as control in Rivers State of Nigeria”. Hepcidin, sTfR, Ferritin, Iron, TIBC and UIBC were assayed using Enzyme Linked Immunosorbent Assay and Photometric methods”. Data was analyzed using (Graph Pad Prism version 9.0, and NCSS version 9.0). “Results obtained were expressed mean ± SD, median and 2.5-97.5 percentile. Hepcidin concentration declined throughout the three partitions of pregnancy (p<.05) and had greatest sensitivity than other iron parameters at week 20 and 30. The AUCROC values for hepcidin to detect iron deficiency (ferritin <15ng/ml) were 0.96, p<.0001 and 0.97, p<.0001 at weeks 20 and 30 respectively. The prevalence of anaemia increased from 39.37%, to 89.33%, and 60.37%, at weeks 12, 20, and 30 respectively. The prevalence of iron deficiency anaemia defined as (sTfR>28nmol/l) was 17.99% at week 12, 17.68% at 20 and 35.98% at week 30. Hepcidin outperformed haemoglobin, ferritin, soluble transferrin receptor in diagnosing iron deficiency. This study found a progressive increase in development of IDA, even with increase iron demand by fetus economic. We had provided data and evidence on changes in serum hepcidin concentration and other iron parameter in pregnancy, and further asserts that hepcidin is a more useful assay in diagnosis of IDA in pregnancy.

Keywords: Hepcidin, Gestation, Women, Rivers State.

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Corresponding Author

Beauty Echonwere

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