Details
Category: Volume 06 Issue 11 November 2018
Hits: 1199

Title: Study on RDW (Red Cell Distribution Width) in Relation to RV Diastolic Dysfunction in COPD Patients

Authors: Tameem Imran, Prabhakar K, Rumaisa Ahmed

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i11.39

Abstract

COPD has a systemic inflammatory effect which extends beyond the pulmonary system resulting in a state of persistent low-grade systemic inflammation and this inflammation has been proposed as a key element in the association of COPD and CVD. Recently there has been growing attention given to the relationship between RDW and cardiovascular disorders, such as heart failure and coronary artery disease. The present study is conducted to see the relationship between RDW (red cell distribution width) in the relationship with right ventricle diastolic dysfunction in COPD patients. An Observational study conducted at R L Jalappa Hospital Kolar from January to June 2018 which included 98 patients. There is a statistically significant difference were observed in relationship to RDW and with parameters RV basal diameter, RV systolic pressure, RV wall thickness, RV mid cavity diameter, RV longitudinal diameter, Tricuspid E/A, Tricuspid S, Tricuspid e’,’ Tricuspid e’/a’,. And Tricuspid E/e’, S velocity and TAPSE except for Tricuspid E' and Tricuspid A'.26 members had RV Diastolic Dysfunction with RDW > 14.5 whereas only 4 members with RDW <14.5 and this is statistically significant. (Chi-square value of 37.6).The present study troughed some light that there might be a relationship between the increased level of RDW and RV diastolic dysfunction in COPD patients.

Keywords: COPD, CVD, RDW, Kolar, Karnataka.

References

  1. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380(9859): 2095-128.
  2. Gold reports 2018 – Global Initiative for Chronic Obstructive Lung Disease: https://goldcopd.org/gold-reports/. Accessed on 11th Oct 2018.
  3. Chronic obstructive pulmonary disease: https://en.wikipedia.org/wiki/Chronic_obstructive_pulmonary_disease.  Accessed on 5th Sep 2018
  1. Sin DD, Man SF. Impact of cancers and cardiovascular disease in chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2008;14(2):115-21.
  2. Maclay JD, MacNee W. Cardiovascular disease in COPD: mechanisms. Chest. 2013 Mar;143(3):798-807
  3. John D.Maclay, William McNee. Cardiovascular Disease in COPD: Mechanisms. Chest. Volume 143, Issue 3, March 2013, Pages 798-807
  4. Jennifer Quint. The Relationship between COPD and Cardiovascular Disease. Tanaffos. 2017; 16(Suppl 1): S16–S17.
  5. Morgan AD, Zakeri R, Quint JK. Defining the relationship between COPD and CVD: what are the implications for clinical practice? .Ther Adv Respir Dis. 2018 Jan-Dec;12.
  6. Celli BR, Zuwallack RL. Pulmonary rehabilitation. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 105.
  7. Forhecz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohaszka Z, Janoskuti L. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009; 158:659e66.
  8. Dharmesh kumar Patel, Deepali J. Kamdar. Prediction of the severity of COPD based on red cell distribution width value. Indian Journal of Immunology and Respiratory Medicine, October-December 2016;1(4):84-87.
  9. Atac Celik, Fatih Koc, Hasan Kadi, Koksal Ceyhan, Unal Erkorkmaz et al. The relationship between red cell distribution width and echocardiographic parameters in patients with diastolic heart failure. Kaohsiung Journal of Medical Sciences (2012) 28, 165-172.
  10. Sen Liu, Ping Wang, Ping-Ping Shen, and Jian-Hua Zhou. Predictive Values of Red Blood Cell Distribution Width in Assessing Severity of Chronic Heart Failure. Med Sci Monit, 2016; 22: 2119-2125.
  11. Patel KV, Semba RD, Ferrucci L, et al. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci 2010; 65:258-65.
  12. Riedl J, Posch F, Konigsbrugge O, et al. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboem-bolism and mortality. PLoS One 2014;9.

Corresponding Author

Tameem Imran

Email:  This email address is being protected from spambots. You need JavaScript enabled to view it., Mob: 8971254642