Title: Case Report of Giant Phyllodes

Authors: Mahendra S. Navare, Priya Ahire, Tanvi M. Shah, Rajashri Kelkar

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i9.40

Abstract

Phyllodes tumours are rare breast tumours. These fibro-epithelial neoplasms are classified as benign, borderline & malignant based on stromal & cellular patterns, but a reliable classification is challenging. The diagnosis is based on core needle biopsy. Treatment of choice is surgical excision with negative margins. We report the case of a giant phyllodes tumour weighing 4kg that was successfully managed with surgical excision.

Keywords: giant phyllodes.

References

  1. L Bernstein, D Deapen, R K Ross; the descriptive epidemiology of malignant cystosarcoma phyllodes tumours of the breast, cancer 71 (10) (1993) 3020-3024.
  2. IARC, WHO classification of tumours of the breast, in: S Lakhani et al (Eds). Vol. 4, IARC, Lyon, France, 2012.
  3. Y Zahang, C. G Kleer, phyllodestumour of the breast: histopathologic features, differential diagnosis & molecular genetic updates, Arch. Pathol. Lab. Med. 140 (7) (2016) 665-671
  4. Malignant phyllodes tumor of the breast: review of the literature and case report of stromal overgrowth. AU Guerrero MA, Ballard BR, Grau AM SO Surg Oncol. 2003; 12(1):27.
  5. Phyllodes tumors of the breast: a review of 32 cases. Geisler DP, Boyle MJ, Malnar KF, McGee JM, Nolen MC, Fortner SM, Broughan TA: Am Surg. 2000; 66(4):360.
  6. Phyllodes tumors of the breast: Authors:Ana M Grau, MD, FACSA Bapsi Chakravarthy, MD, FASTRORashmi Chugh, MDSection Editors:Lori J Pierce, MDDaniel F Hayes, MDAnees B Chagpar, MD, MSc, MA, MPH, MBA, FACS, FRCS(C)Deputy Editor:Wenliang Chen, MD, PhD
  7. Clinicopathologic features and long-term outcomes of 293 phyllodes tumors of the breast. Barrio AV, Clark BD, Goldberg JI, Hoque LW, Bernik SF, Flynn LW, Susnik B, Giri D, Polo K, Patil S, Van Zee KJ: Ann Surg Oncol. 2007;14(10):2961.
  8. Cystosarcoma phyllodes: a clinicopathologic analysis of 42 cases. Pietruszka M, Barnes L: Cancer. 1978;41(5):1974.
  9. Retrospective analysis of 25 women with malignant cystosarcoma phyllodes--treatment results. SoumarováR, SeneklováZ, HorováH, VojkovskáH, HorováI, BudíkováM, RůzickováJ, JezkováB : Arch Gynecol Obstet. 2004;269(4):278.
  10. Salvadori B, Cusumano F, Del Bo R, Delledon V, Grassi M RoviniD, et al: Surgical treatment of phyllodes tumours of breast. Cancer 1989, 63:2532-36
  11. Mangi AA, Smith BL, Gadd MS, Tanabe KK, Otto MJ, Souba WW: Surgical management of phyllodes tumours. Arch Surg 1999, 134:487-93
  12. Cheung HS, Tse GMK, Ma TKF: Correspondence. Clin Radiol 2002, 57: 230-31
  13. Krishnamurthy S, Ashfaq R, Shin HJ. Sneige N: Distinction of phyllodes tumour from fibroadenoma: a reappraisal of an old problem. Cancer 2000. 90: 342-49
  14. Chua CL, Thomas A, Ng BK: Cystosarcoma phyllodes: a review of surgical options. Surgery 1989, 105: 141-47
  15. Sheen-Chen SM, Chou FF, Chen WJ: Cystosarcoma phyllodes of the breast: a clinical, pathological & therapeutic option in 18 cases. Int Surg 1991. 76: 101-04
  16. Norris HJ, Taylor HB: Relationship of histologic features to behaviour of cystosarcoma phyllodes- analysis of 94 cases. Cancer 1967 20:2090-99
  17. Chaney AW, Pollack A, McNeese MD, Zagrars GK: Adjuvant radiotherapy for phyllodes tumour of breast. Radiat oncol investing 1998, 6:289-90
  18. Tan PH, Jaybaskar T, Chuah KL, Lee HY, Tan Y, Hilmy M et al: Phyllodes tumours of the breast: the role of pathologic parameters. Am J Clin Pathol 2005, 123:529-40
  19. Browder W McQuitty JT, McDonald JC: Malignant cystosarcoma phyllodes: treatment & prognosis. Am J Surg 1978, 136: 239-41
  20. Kessinger A Foley JF, Lemon HM, Miller DM: Metaststic cystosarcoma phyllodes: a case report & review of literature. J Surg Oncol 1972, 4: 131-47
  21. Hines JR, Murad JM, Beal JM: Prognostic indicators in cystosarcoma phyllode. Am J Surg 1987, 153: 276-80
  22. Khanna S, Gupta S, Khanna NN: Sarcomas of the breast: homogenous or heterogenous? J Surg Oncol 1981: 119-28
  23. Cohn-Cedermark G, Rutqvist LE, Rosendahl I, Silversward C: Prognostic factors in cystosarcoma phylodes: a clinic-pathological study of 77 patients. Cancer 1991, 68: 2017-22
  24. Phyllodes tumours of the breast: a clinicopathological analysis of 65 cases from a single institution. Karim RZ, Gerega SK, Yang YH, Spillane A, Carmalt H, Scolyer RA, Lee CS : Breast. 2009;18(3):165.
  25. Phyllodes tumors of the breast diagnostic and therapeutic dilemmas. FajdićJ, Gotovac N, HrgovićZ, Kristek J, Horvat V, Kaufmann M: Onkologie. 2007;30 (3):113.
  26. Phyllodes tumors of the breast: natural history, diagnosis, and treatment. Telli ML, Horst KC, Guardino AE, Dirbas FM, Carlson RW: J Natl Compr Canc Netw. 2007;5(3):324.
  27. Surgical treatment of borderline and malignant phyllodes tumors: the effect of the extent of resection and tumor characteristics on patient outcome. Onkendi EO, Jimenez RE, Spears GM, Harmsen WS, Ballman KV, Hieken TJ : Ann Surg Oncol. 2014 Oct;21(10):3304-9. Epub 2014 Jul 18.

Corresponding Author

Dr Tanvi M Shah

107, Hilla towers, A- wing, Dr SS Rao road, Lalbaug, Mumbai 400012, India

Mob: 9967215979. Email: This email address is being protected from spambots. You need JavaScript enabled to view it.