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Category: Volume 06 Issue 09 September 2018
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Title: Study of Liver and Kidney Biochemical Variations in Patients with Various Morphological Types of Leukemia at a Tertiary Healthcare Hospital

Authors: Dr Shruti Singh (M.D), Dr Poonam Woike (M.D), Dr Rajesh Gaur (M.D), Dr D. Nath (M.D)

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i9.32

Abstract

Leukemias are malignant neoplasm of the haematopoietic stem cells, arising in the bone marrow that flood the circulating blood or other organs. The objective of this study was to find out the effect of leukemia on liver and renal function of the patients at our institute. Present study is a prospective study which includes the findings and observations of 25 patients diagnosed with leukemia of various types such as acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia and chronic lymphocytic leukemia. Diagnosis of the patients were made by their peripheral smear examination and various parameters counted by automated haematology analyzer and their confirmation was made by using special stains and bone marrow examination.  Liver and renal function tests were performed in the patients and results were observed. In acute myeloid leukemia liver function tests were found altered with mainly rise in serum alkaline and alanine transferase, in acute lymphoblastic leukemia, there was marked increase in alkaline phosphatase with normal or decreased SGOT and SGPT value, in chronic myeloid leukemia increase in uric acid was observed with slight fluctuating values in SGOT/SGPT but no significant changes were seen in patients with chronic lymphocytic leukemia.

Keywords: Leukemia, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia.

 

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Corresponding Author

Dr Poonam Woike

Address- House No. 08, H-Block, Faculty Quarters, Near 29 Batallion Street, Datia, M.P, India

Phone No- 7745983670