Title: Detection of an asymptomatic non-palpable non-lymphomatous CD8+ splenic hamartoma

Authors: Ashok Kumar Kapoor, Anil Kumar Verma, Kanhaiya Lal Mishra, Surabhi Maheshwari

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i9.19

Abstract

Present case report relates to the incidental finding of a splenic hamartoma during a medical check-up.  Later, splenectomy was done. Tumor measured 3.5×3×3 cms. Microscopic examination of tumor showed unencapsulated disorganized tortuous vascular spaces of variable width, lined by plump endothelial cells.  Immunohistochemical (IHC) examination of lining endothelial cells with anti-CD8+ antibody revealed a positive reaction. Anti-CD8+ positivity suggested the tumor to be a splenic hamartoma.  It is a rare benign tumor. Present tumor was arising from red pulp (type II splenic hamartoma).

Keywords:  Benign, embryonic, immunohistochemistry, splenectomy, tumor malformation, vascular.

References

  1. Lee H, Maeda K. Hamartoma of the spleen.  Arch Pathol Lab Med 2009; 133:147-151.
  2. Sim J, Ahn HI, Han H, Jun YJ, Rehman A, Jang SM, Jang K. Splenic hamartoma : A case report and review of the literature.  World J Clinical cases 2013, 1(7):217-219.
  3. Silverman ML, Livolsi VA. Splenic hamartoma. Amer J Clin Pathol 1978; 70 : 224-229.
  4. Sankar S, Thanka J, Jagdishchandrabose S, Rajendran S. Splenic hamartoma : a rare vascular space occupying lesion of the spleen.  Indian J PatholMicrobiol 2011; 54: 223-225.
  5. Zhang L, Tou J, Wang X, GuW, Ma X, Qin Q. Splenic hamartoma in two children. World J Surgical Oncology 2014; 12:180-184.
  6. Vlachou P, Fagkrezos D, Tzivelopoulou, Kyriakopoulou G, Maniatis P, Triantopoulou C, Papailiou J. A rare case of a splenic hamartoma in a patient with a huge palpable abdominal mass : a case report. J of medical case reports 2015; 9:4.
  7. Basso SMM, Sulfaro S, Marzano B, Fanti G, Chiara GB, Lumachi F, Incidentally discovered asymptomatic splenic hamartoma with rapidly expansilegrowth : A case report. In Vivo 2012; 26 : 1049-1052.
  8. Hayes TC, Britton HA, Mewborne EB, Troyer DA, Saldivar VA, Ratner IA. Symptomatic splenic hamartoma : Case report and literature review.  Pediatrics 1998; 101 (5) : 1-6.
  9. Eker T, Kocaay AF, Sevim Y, Cakmak A. Splenic hamartoma is a rare cause of abdominal pain : case report and literature review.  Ulus Cerrahi Derg 2015, DOI : 10.5152/UCD. 2015.3048.
  10. Darden JW, Teeslink R, Parish A. Hamartoma of the spleen : a manifestation of tuberous sclerosis.  Ann Surg 1975; 41 : 564-566.
  11. Huff DS, Lischner HW, Go HC, DeLeon GA. Unusual tumors in two boys with Wiskott-Aldrich-like syndrome. Lab Invest. 1979; 40 : 305-306.
  12. Tavangar SM, Abdollahi A. Splenic hamartoma: Immunohistochemical profile.  Acta Medica Iranica 2017; 55(1) : 77-78.
  13. Elenga N, Labbe S, Leduc N, Sika A, Cuadro E, Long L, Njuieyon F, Kom-Tehameni R, Basset T.  Asymptomatic multinodular splenoma (splenic hamart-oma) in a child with sickle cell anemia.  Int Med Case Rep 2017; 10:233-236.

Corresponding Author

Dr Ashok Kumar Kapoor

Pathologist, Department of Pathology, RML Mehrotra Pathology Pvt Limited

B 171, Nirala Nagar, Lucknow-226020, Uttar Pradesh, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.