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Category: Volume 06 Issue 09 September 2018
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Title: A Clinicopathological Study of Placenta in Health and Maternal Diseases

Authors: Shilpa Jawahar Patil, Shantilal Mohanlalji Sisodia, Bharat Ankush Ghodke

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i9.17

Abstract

Background: Our Aim was to study the frequency of maternal diseases along with gross and microscopic findings in placenta of normal term pregnancy& also pregnancy with complications

Methods: A two years prospective study of all the placenta received was sent for histopathological examination, where sections from membrane, umbilical cord & serial section from placental cotyledon were processed which were stained with Hematoxylin and Eosin stain for routine purpose. Special stains like PAS and Masson’s trichome were used whenever indicated.

Result: The most common risk factor is hypertension 31/143 (21.08%) followed by fever 20/143 (13.9%), diabetes 5/143 (3.4%), Infectious causes like varicella, hepatitis HIV, VDRL were observed. Among the HIV positive cases, chorioamnionits is present in 100% cases, deciduitis in 75%, perivillous fibrin 75% and calcification in 25% cases. In pregnancies with poor foetal outcome of which the most common is IUGR 39/143 (27.3%), followed by IUFD and still births 30/143 (21.6%).

Conclusion: Most common pregnancy related risk factor was hypertension ,followed by maternal fever..The histological lesions in descending order were Chorioamnionitis 17 out of 30 cases (56.6%), infarct 11 out of 30 cases (36.6%), deciduitis 10 out of 30 cases (33.3%), fibrinoid necrosis  9 out of 30 cases (30%), funisitis 7 out of 3(23.3%) also present were Inflammation of membrane, cord and decidua which led to uteroplacental insufficiency and poor pregnancy outcome. Examination of placenta is essential for  the histological diagnosis of the disease which may not be suspected by the obstetrician

Keywords: Placenta, histopathology, foetus, hematoxylin.

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Corresponding Author

Bharat Ankush Ghodke

Flat No-25, 6th Floor, Parijat CHS, Bldg No-MN-1, Kashish Park, LBS Marg, Thane-West, 400604, India

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