Title: Prevalence of Extended-Spectrum β-Lactamases producing Klebsiella pneumoniae isolates in a tertiary care hospital in South India
Authors: Rangnekar Aseem, Mallaya Shrikara, Shenoy Shalini, Gupta Shefali
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.129
Abstract
Background: Growing antimicrobial resistance is of great concern in modern antibiotic era. Infections caused by multidrug resistant organisms like Klebsiella pneumoniae are among the leading causes of sepsis and infection related deaths.
Aim: This study was done to determine the prevalence of ESBL producing Klebsiella in the various clinical specimens by phenotypic methods.
Material and Methods: A prospective laboratory based study was done to determine phenotypically detect the presence of Extended Spectrum β-lactamases (ESBL’s) in samples received over a period of two years. A total of 7644 gram negative bacterial isolates were recovered from a total of 16526 clinical specimens received in the microbiology laboratory, over the two year period. Among the 2497 isolates of Klebsiella, 1157 isolates were ESBL positive (46%).
Conclusion: Drug resistant Klebsiella producing ESBL are hard to treat, and infections caused by them can lead to fatal outcome. Effective antibiotic policy and rational use must be strongly and promptly implemented in all healthcare setups.
Keywords: ESBL, Antibiogram, Drug resistant Klebsiella pneumoniae.
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