Title: A Comparative Study of Ropivacaine with Dexmeditomidine and Fentanyl Spinal Anaesthesia in Uro-Gynacological Surgeries

Authors: Pratibha Kumari, Ramu Valluri, Geetha P Parikh, Veena.R.Shah

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.110

Abstract

This study was conducted in 106 adult patients with ASA physical status I-II  planed for lower abdominal uro -gynac surgeries under spinal anaesthesia. We compared  the onset & duration of motor and sensory block and time to two segment regression from maximal level achieved after giving 2.5ml of 0.75% Ropivacaine + 5µg dexmeditomidine (group-RD) versus 2.5 ml of 0.75% Ropivacaine + 25µg fentanyl intrathecally(group-RF).We observed that onset of sensory and motor blocks  were not statistically significant in both groups. Duration of complete motor & sensory blocks were significantly shorter in group-RF as compared to group-RD. Time to 2 segment regression of sensory blockade from maximum level  was statistically significant in group-RF compared to RD group.  Haemodynamic parameters were comparable in both groups. Demand for rescue analgesia was later and number of doses of rescue analgesia was lesser in group RD Peri-operative and post-operative complications were less & comparable in both groups.To conclude, we found that intrathecal (5µg) DXM supplementation with 0.75% ropivacaine seems to be a better alternative to intrathecal (25µg) fentanyl with 0.75% ropivacaine since it produces prolonged sensory& motor  blockade and more effective pain relief, thus making it a more lucrative option for lower abdominal  and uro-gynacological surgeries.

Keywords: spinal anaesthesia, Ropivacaine, Dexmeditomidine, fentanyl, uro-gynacological surgeries

References

  1. Delfino J.,Pontes S.,Gondim D.,Do Vale N.,Isobaric 0.5% bupivacaine & 0.5% ropivacaine in spinal anesthesia for orthopaedic surgery,: a comparativestudy, REV.BRAS.ANESH.,49(3),160-164,1999.
  2. McClellan KJ, Faulds D. Ropivacaine: an update of its use in regional anaesthesia. Anesth Analg. 2000 Nov; 60(5):1065-93.
  3. Kallio H, Snall EV, Kero MP, Rosenberg PH. AComparison of intrathecal plain solutions containing ropivacaine 20 or 15 mg versus bupivacaine 10mg. Anesth Analg 2004; 99: 713-717.
  4. Kallio H, Snall EV, Survanto SHJ, Tuomas CA, Iivonrn MK, Pokki JP et al. Spinal hyperbaric ropivacaine-fentanyl for day-surgery.Reg Anesth pain Med 2005; 30:48-54.
  5. Kanazi GE,Aouad MT,Jabbour-Khoury SI,AL Jazzar,Alameddine MM,Al –Ya-man R Bulbul M,Baraka AS.Effect of low dexmeditomidine or clonidine on the characteristics of bupivacaine spinal block. Acta Anesthesiol Scand 2006;50:222-227.
  6. Kallio H, snall EV, Tuomas CA, Rosenberg PH. Comparison of hyperbaric and plain ropivacaine 15mg in spinal anaesthesia for lower limb surgery. Br J Anaesth 2004; 93: 664-669.
  7. Seewal R,Shende D,Kashyap L,Mohan V.Effect of addition of various doses of fentanyl intrathecally to 0.5% hyperbaric bupivacaine on perioperative analgesia & subarachnoid- block characteristics in lower abdominal surgery:a dose response study.Reg anesth pain Med.2007 Jan-Feb;32(1):20-6.
  8. M Mantouvalou, S Ralli, H Arnaoutoglou, G Tziris, G Papadopoulos. Spinal anesthesia: Comparison of plain ropivacaine, bupivacaine and levobupivacaine for lower abdominal surgery. Acta Anaesth. Belg. 2008; 59:65-71.
  9. Taspinar V, Sahin A, Donmez NF, Pala Y, Selcuk A, Ozcan M, Dikmen B: Lowdose ropivacaine or levobupivacaine walking spinal anesthesia in ambulatory inguinal herniorrhaphy. J Anesth. 2011 Apr; 25(2):219-24.
  10. Subhi M.AL-Ghanem,et al.:Effect of adding dexmeditomidine v/s Fentany to intrathecal bupivacaine on spinal block characteristics in gynaecological procedures:American J of Applied science 6(5):882-887,2009.
  11. Rajni Gupta,,Reetu Verma.et al.: A Comparative study of intrathecal dexmeditomidine & fentanyl as adjuvants to Bupivacaine.J Clin Anesth July-Sept 2011.
  12. Sukhminder jit singh Bajwa ,et al : comparative evaluation of dexmeditomidine and fentanyl for epidural analgesia in lower limb orthopaedic surgeries.2011 oct-dec;5(4):365-370.

Corresponding Author

Pratibha Kumari

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Phone No: 9959098151