Title: Vitamin D Deficiency in Asthmatics from an Urban Population in India

Author: Dr Mohammed Soheb Sadath Ansari

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.38

Abstract

Background: Indian population is deficient in the sunshine vitamin inspite of availability of plenty of sunshine. Vitamin D deficiency is endemic problem in India with a prevalence of 70-100%. On the other hand Asthma is also on rise and in spite of the best available treatment the control of Asthma is poor in our population. Is Vitamin D deficiency which is rampant in our country, one of the factors responsible for this poor control? Dietary habits and indoor life styles may be responsible for the deficiency of Vitamin D. The impact of Vitamin D on Asthma is becoming an important area of research.

Material and Methods: A total of 205 Asthma patients were enrolled and their Vit D levels were assessed by CLIA (chemiluminescence Immune assay ) and graded as deficient, insufficient and normal. The Asthma patients were under follow up since one year and their level of control was assessed as per GINA guidelines. The percentage of well controlled among the three groups of Vit D levels were recorded.

Results: From among a total of 205 Asthma patients 55.12% were deficient in Vit D

20.48% were having insufficient Vit D levels and 24.39% had normal Vit D levels. The distribution of Vit D deficiency among both sexes was almost same. The level of control among the three groups was also same in our study

Conclusion: Vit D deficiency is rampant among general population as well as Asthma patients. This was shown in our study also. As Vitamin D has anti infective, anti inflammatory and immune modulatory actions this area becomes important for research as it may have significant impact on Asthma.

Keywords:  Vitamin D Asthma Deficiency.

References

  1. Cavkaytar O1, Sekerel BE Baseline management of asthma control.Allergol Immunopathol (Madr). 2014 Mar-Apr;42 (2):162-8. doi: 10.1016/j.aller.2012.10.004. Epub 2012 Dec 21.
  2. Ritu G1 and Ajay Gupta1,2,Vitamin D Deficiency in India: Prevalence, Causalities and Interventions. Nutrients. 2014 Feb; 6(2): 729–775.
  3. Beloyartseva M., Mithal A., Kaur P., Kalra S., Baruah M.P., Mukhopadhyay S., Bantwal G., Bandgar T.R. Widespread vitamin D deficiency among Indian health care Arch. Osteoporos. 2012;7:187–192.
  4. Bhutta ZA. Vitamin D and child health: some emerging issues. Maternal and Child Nutrition, 2008, 4(2):83–85.
  5. Wagner CL, Taylor SN, Hollis BW. Does vitamin D make the world go 'round'? Breastfeed Medicine, 2008, 3(4):239–250.
  6. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Archives of Internal Medicine, 2007, 167:1730–1737.
  7. Manaseki-Holland S et al. Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial. Tropical Medicine and International Health, 2010, 15(10):1148–1155.
  8. Vitamin D and asthma. Mak G, Hanania NA. Curr Opin Pulm Med. 2011;17:1–5.
  9. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. Brehm JM, Schuemann B, Fuhlbrigge AL, et al. J Allergy Clin Immunol. 2010;126:52–58.
  10. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Gupta A, Dimeloe S, Richards DF, et al. Thorax. 2014;69:508–515.
  11. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Brehm JM, Acosta-Perez E, Klei L, et al. Am J Respir Crit Care Med. 2012;186:140–146.
  12. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. Majak P, Olszowiec-Chlebna Mg, Smejda K, et al. J Allergy Clin Immunol. 2011;127:1294–1296.
  13. Nasrin Esfandiar1, Fariba Alaei2, Shahrzad Fallah3, Delara Babaie4 and Niloofar Sedghi1. Vitamin D deficiency and its impact on asthma severity in asthmatic children. Italian Journal of Pediatrics (2016) 42:108
  14. Sabah F Iqbal, MD1,2,3 and Robert J Freishtat, MD, MPH1,2,3 The Mechanism of Action of Vitamin D in the Asthmatic Lung. J Investig Med. 2011 Dec; 59(8): 1200–1202.
  15. Banerjee A, Damera G, Bhandare R, et al. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br J Pharmacol. 2008 Sep; 155(1):84–92.
  16. Poon AH, Laprise C, Lemire M, et al. Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Respir Crit Care Med. 2004 Nov 1;170(9):967–973
  17. Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl) May;88(5):441–450.
  18. Banerjee A, Damera G, Bhandare R, et al. Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br J Pharmacol. 2008 Sep;155(1):84–92.
  19. A case-control study of vitamin D status and asthma in adults. Devereux G, Wilson A, Avenell A, et al. Allergy. 2014;65:666–667.
  20. Elena Lewis1& Thomas Casale† Role of vitamin D in asthma. Therapy (2011) 8(3), 297–306

Corresponding Author

Dr Mohammed Soheb Sadath Ansari

Associate Professor, Department of Respiratory Medicine

Bhaskar Medical College, Moinabad, Hyderabad, Telangana, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Cell: 91-9573593652