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Category: Volume 06 Issue 07 July 2018
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Title: Comparison of Intubating Conditions of Rocuronium Bromide and Vecuronium Bromide in Thyroid Surgery Using Train of Four

Authors: Dr Arun Kumar Mohanty, Dr Ramakanta Mohanty, Dr Sidharth Sraban Routray, Dr Sasmita Sahoo

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i7.18

Abstract

Background & Aim: Rocuronium and vecuronium are commonly used nondepolarising muscle relaxants which are monoquaternary aminosteroid compounds. The aim of this study was to study the onset time, conditions of intubation and duration of action of equipotent doses of rocuronium and vecuronium.

Methods: 60 patients were divided into two groups of 30 each. Patients allocated to Groups A and B received rocuronium 0.6 mg kg -1 and vecuronium 0.1 mg kg -1 respectively. Tracheas were intubated after train of four count become zero in adductor pollicis muscle. Intubating conditions, onset time and duration of neuromuscular block were assessed both group A and B. Haemodynamic variables were compared at 1,3 and 5 minutes after intubation.

Results: The mean onset time was significantly rapid in Group A as compared to Group B.Intubating conditions were excellent in 86% of patients in Group A as compared to 80% in Group B. The mean duration of action and hemodynamic parameters did not show any significant variation between the two groups.

Conclusion: In comparison to vecuronium, rocuronium provides earlier acceptable intubation conditions without significant variation in duration of action and hemodynamics.

Keywords:  rocuronium, train of four, vecuronium, intubation.

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Corresponding Author

Dr Ramakanta Mohanty

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