Title: A Study of Clinical Profile of Empyema Thoracis Patients in Tartary care center at Agra

Authors: Gajendra Vikram Singh, Santosh Kumar, Rishabh Goel, Benhur Joel Shadrach, Chandrakant Khachru Khandare

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i5.111

Abstract

Background: Pleural infection is one of the oldest and most severe diseases. Prompt recognition of the development of empyema is crucial to successful treatment. Even with appropriate therapeutic attempts, mortality of patients is 15-20% and higher in immunocompromised patients. The present study was carried out to study the clinical profile of empyema thoracis patients in a tertiary care center. 

Methods: 56 patients were included in this prospective study who were diagnosed as case of empyemas thoraces over a period of 12 months. An evaluation of clinical features, associated risk factors or co-morbidities, causative organisms, treatment modalities and outcome of these patients was carried out.

Results: There were 56 patients included in the study out of which, 52% patients belonged to age group 18-40 years with a significant male preponderance. 75% patients were of tubercular origin and rest were of bacterial origin, most commonly, Staphylococcus aureus, followed by gram negative bacilli . Most frequently associated co-morbidity was found to be Pneumonias followed by diabetes, smoking and alcohol abuse. Most commonly used management modality was ICT drainage which provided maximum drainage and also reduces the hospital stay. 

Conclusion: Empyema thoracis has a very high prevalence in developing countries like India. Amongst which, tubercular empyemas, being most common in young adults is a major cause of morbidity and mortality.

Keywords: Empyemathoracis, Pneumonia, Tuberculosis.

References

  1. Adams F: The genuine works of Hippocrates. Baltimore William and Wilkins Company.1939; p51-2.
  2. Light RW,Girad WM, Jenkinon SG et al. Parapneumonic effusion. Ann J Med 1980; 69: 507-11
  3. Teixeira LR, Sasse SA, Villarino MA, Nguyen T, Mulligan ME, Light RW. "Antibiotic levels inempyemic pleural fluid". Chest.2000; 117(6): 1734–9. 
  4. Umut S, Demir T,Akkan G, Keskiner N, Yilmaz V, Yildrim N, Sipahioglu B, Hasan A,BarlasA, Sozer K, Ozuner Z. "Penetration of ciprofloxacin into pleural fluid". Journal of Chemotherapy 1993; 5 (2): 110–112
  5. Idell S, Girard W, Koenig KB, McLarty J, Fair DS. Abnormalities of pathways of fibrin turnover in the human pleural space. Am Rev RespirDis.1991;144:187–194.
  6. Strange C, Allen ML, Harley R, Lazarchick J, Sahn SA. Intrapleural streptokinase in experimental empyema. Am Rev Respir Dis.1993;147: 962–966.
  7. Katariya K, Thurer RJ. Surgical management of empyema. ClinChes Med. 1998; 19:395–406.
  8. Sherman MM, Subramanian V, Berger RL. Management of thoracic empyema. Am J Surg. 1977; 133:474–9
  9. Kamat A prospective study of 100 cases of chronic empyema in Bombay. Lung India.1985; 3:15–9.
  10. Maskell NA et al.N Engl J Med.2005 Mar 3;352(9):865-74.
  11. Malhotra P, Aggarwal AN, Agarwal R, Ray P, Gupta D, Jindal SK. Clinical characteristics and outcome of empyema thoracis in 117 patients. A comparative analysis of tubercular vs. nontubercular aetiologies. Respir Med. 2007;101:423–30
  12. Vardhan MV, Tewari SC, Prasad BN, Nikumb SK. Empyema thoracis- study of present day clinical and etiological profile and management techniques. Ind J Tub. 1998;45:155–60.
  13. Goyal SP, Tandon RK, Patney NL, Mishra OP. Management of tubercular empyema thoracis: A review of 53 cases. Ind J Tub. 1976;23:103–9.
  14. Acharya PR, Shah KV. Empyema thoracis: A clinical study. Ann Thorac Med. 2007;2:14–7.
  15. Madan A, Sharma TN, Jain NK, Sarkar SK, Durlabhji P. Tubercular empyema thoracis: A diagnostic and therapeutic problem. Indian J Chest Dis Allied Sci. 1993;25:127–31.
  16. Banga A, Khilnani GC, Sharma SK, Dey AB, Wig N, Banga N. A study of empyema thoracis and role of intrapleural streptokinase in its management. BMC Infect Dis. 2004;4:19.
  17. Tandon RK, Misra OP. Clinicopath-ological study of thoracis empyema and evaluation of its surgical treatment. Indian J Chest Dis. 1974;16:21–30. 
  18. Singh V, Behra RK, Jain NK. Anaerobic bacteriology of empyema. Lung India. 1983;1:12–5.
  19. Rao B, Kumar VV, Kumara H.To Study the Clinical Profile of EmpyemaThoracis in the Patients Admitted in Government Hospital for Chest and Communicable Diseases,Visakhapatnam IJSR. 2016; 5(8):68-73
  20. Kundu S, Mitra S, Mukherjee S, Das S. Adult thoracic empyema: A comparative analysis of tuberculous and non tuberculous etiology in 75 patients. LungIndia2010 Oct-Dec; 27(4): 196–201.
  21. Winterbauer RH. Nonmalignant pleural effusions. In: Fishman AP, Fishman JA, Grippi MA, Kaiser LR, Senior RM, editors. Fishman's Pulmonary Diseases Pulmonary Diseases and Disorders. 3rd ed. New York: McGraw-Hill; 1998. pp. 1411–28.

Corresponding Author

Dr Santosh Kumar

Associate Professor and Head, Department of T.B. & Chest Diseases

S.N. Medical College, Agra, India

Mob: 9897517869, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.