Title: A Comparative study for Diagnostic Evaluation of Polycystic Ovarian Syndrome (PCOS) by Estimation of High Sensitivity C - reactive protein (hsCRP) and Insulin Resistance
Authors: Dr Sangita Biswas, Dr Sujit Kumar Dey
DOI: https://dx.doi.org/10.18535/jmscr/v6i5.13
Abstract
Now-a-days infertility is an emerging problem involving the women with reproductive age group. Polycystic ovarian syndrome (PCOS) is one of the leading cause that affects etiology of infertility to a great extent. Hyperandrogenism, Amenorrhea and Polycystic ovaries characterize the disease. Long term complication include DM Type II, Obesity, Heart disease and Endometrial cancer. Our study was aimed to compare the level of Insulin Resistance (IR) and serum hsCRP (a marker of low grade inflammation) among PCOS patients and controls and specifically to determine whether there was any correlation between Insulin resistance and hs-CRP level among PCOS patients. In search of suitable markers for diagnosis as well as management of such patients, this case control study was conducted among 44 PCOS cases and 44 non-PCOS age matched controls. Serum Fasting Blood Sugar (FBS) by GOD-POD method in auto analyzer, hs-CRP and Fasting Insulin by enzyme linked immunosorbent assay were measured. Insulin resistance was calculated by HOMA-IR. Unpaired‘t’ test was used to compare different means between two groups .Statistical correlation was tested between hsCRP and Insulin resistance to find any association. Statistically significant differences of means were observed in the values of Fasting Insulin, hs-CRP and IR between cases and controls as the ‘p’ values were <0.05. No such statistically significant difference was observed between means of FBS and correlation between Insulin Resistance and hs-CRP among PCOS cases. So the study concluded that PCOS patients have high level of mean Fasting Insulin, hs-CRP and Insulin Resistance than controls.
Keywords: PCOS, FBS, Fasting insulin, hs-CRP, HOMA-IR, insulin resistance.
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