Title: Association between Glycated haemoglobinand Serum Lipid Profile in Type 2 Diabetic Patients in Kumaun Region, Uttarakhand
Authors: Govind Singh, Shrimanjunath Sankanagoudar, Dinesh Bure
DOI: https://dx.doi.org/10.18535/jmscr/v6i3.58
Abstract
Type 2 diabetes is known to have increased prevalence of lipid abnormalities leading to high risk of cardiovascular diseases (CVD). Diabetic patients are at more risk for altered lipid profile than normoglycemic persons. Glycated hemoglobin (HbA1c) is a routinely used marker for long-term glycemic controland as a screening tool for the diagnosis of diabetes. A value over 6% gives an indication of altered glucose control. Also, HbA1c nowadays is considered an independent risk factor for CVD. In this study association between Glycated haemoglobin (HbA1c) and diabetic dyslipidemia was found. Venous blood samples were collected from 113 type 2 diabetic patients. The whole blood and serum were analyzed for HbA1c, fasting blood sugar (FBS) and lipid profile using cobas c 501 system. The statistical analysis was done by SPSS statistical package version 21. HbA1c showed significant correlations with total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and TC/HDL-C ratio. Patients with HbA1c value > 7.0% had significantly higher value of TC, Triacylglycerol (TG), VLDL-C, LDL-C and TC/HDL-C ratio as compared to the patients with HbA1c ≤ 7.0%. However, there was no significant difference in value of HDL-C between two groups. Thus,HbA1c can be used as a potential biomarker for predicting dyslipidemia in type 2 diabetic patients.
Keywords: Diabetes mellitus, Dyslipidemia, Glycated hemoglobin, Lipid Profile.
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