Title: Association of Ovarian Cancer Risk with Other Gynaecological Diseases in Women- An Observational Study
Authors: Bessy Binu Sam, Kala Bahuleyan Santha, Vishnupriya Prakasan
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.85
Abstract
Background: The most lethal malignancy of the female reproductive system is ovarian cancer. Risk of ovarian cancer increases with age, but the rate of increase slows after the menopause. Several factors have been reported as being associated with the risk of epithelial ovarian cancer, most notably various gynaecological diseases and cancers. This observational study examines the association between ovarian cancer risk and various gynaecological diseases.
Materials and Methods: This study was conducted at Department of Obstetrics and Gynaecology, Government Medical College, Kottayam, Kerala for a period of one year. Data was collected from 448 women of whom 112 women were diagnosed with ovarian cancer. The chi square test was done to find the association of ovarian cancer risk with different gynaecological diseases.
Results: We found out significant association of PCOD, family history of ovarian cancer and fibroid with ovarian cancer. Our study couldn’t find significant association of history of breast cancer and cervical cancer with ovarian cancer.
Conclusions: Overall these results suggest that women with PCOD are at increased risk of ovarian cancer. Family history of fibroid and ovarian cancer also increases ovarian cancer risk. Having multiple benign gynaecologic conditions had a cumulative effect on ovarian cancer risk.
Keywords: Ovarian cancer, fibroid, endometriosis, breast cancer
References
- Gubbels JAA, Claussen N, Kapur AK, Connor JP, Patankar MS. The detection, treatment, and biology of epithelial ovarian cancer. Journal of Ovarian Research. 2010;3:8.
- Iorio MV, Visone R, Di Leva G, Donati V, Petrocca F, Casalini P, et al. MicroRNA signatures in human ovarian cancer. Cancer Res. 2007;67(18):8699-707.
- Ahmed N, Stenvers KL. Getting to Know Ovarian Cancer Ascites: Opportunities for Targeted Therapy-Based Translational Research. Frontiers in Oncology. 2013;3:256.
- Munksgaard PS, Blaakaer J. The association between endometriosis and ovarian cancer: A review of histological, genetic and molecular alterations. Gynecologiconcology.124(1):164-9.
- Sampson J. Endometrial carcinoma of the ovary, arising in endometrial tissue in that organ. Arch Surg 1925;10:1–72.
- Brinton LA, Sakoda LC, Sherman ME, Frederiksen K, Kjaer SK, Graubard BI, Olsen JH, Mellemkjaer L.Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors. Cancer Epidemiol Biomarkers Prev Dec 2005;14:2929–35.
- Kobayashi H, Sumimoto K, Moniwa N, Imai M, Takakura K, Kuromaki T, Morioka E, Arisawa, K, Terao, T.Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan. Int J Gynecol Cancer Jan–Feb 2007;17:37–43.
- Olson JE, Cerhan JR, Janney CA, Anderson KE, Vachon CM, Sellers TA. Postmenopausal cancer risk after self-reported endometriosis diagnosis in the IowaWomen's Health Study. Cancer Mar 1 2002;94:1612–8.
- Stratton JF, Pharoah PDP, Smith SK, Easton DF, Ponder BAJ. A systematic review and meta-analysis of family history and risk of ovarian cancer. Br J Obstet Gynaecol. 1998;105:493–499.