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Category: Volume 06 Issue 01 January 2018
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Title: A Study of Cytomorphological Spectrum of lymphadenopathy in HIV seropositive Patients

Authors: Pista Meena, Anita Harsh, Deepika Hemrajani, Ajay Yadav, Kusum Mathur

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i1.81

Abstract

Background: Lymphadenopathy in HIV/AIDS patients is the earliest andcommonest manifestation of opportunistic infection and malignancies. FNAC is a simple technique which is safe and minimal traumatic to patients.

Aims of Study: To Evaluate the Cytomorphological spectrum of lymphadenopathy in HIV seropositive cases using FNAC technique and to co-relate cytomorphological pattern with Clinical features, CD4 count and Hematological alterations.

Method: The study was conducted in the department of pathology S.M.S. medical college Jaipur from Jan 2016 to end of 2017. FNAC performed on 100 cases with lymphadenopathy. Aspirates stained with H&E and giemsa in routine and special stains whenever indicated.

Result: Out of 100 cases, maximum cases were in age group 26-45 years in 71% with male predominance in 64%. Most common site of lymphadenopathy was cervical region in 72%.Tubercular lymphadenitis was the most common cause of lymphadenopathy in 65% with mean CD4 count 227.40 cells/µl, followed by reactive in 20%, mean CD4 count 546.45cells/µl, suppurative in 11%, mean CD4 count 162.72 cells/µl, lymphoma in 2%, mean CD4 count 565.50 cells/µl and 2% metastatic malignancies, mean CD4 count <100cells/µl. Most common pattern of tubercular lymphadenitis was epithelioid cell granuloma with caseous necrosis seen in 58.46% cases. Grade 1+ was the most common on ZN grading of AFB with mean CD4 count was 257.08 cells/µl.

Conclusion: Tuberculosis was the most common cause of lymphadenopathy. FNAC is a rapid easily performed technique in HIV seropositive cases for early and appropriate diagnosis.

Keywords: HIV, Lymphadenopathy, FNAC, CD4 count.

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Corresponding Author

Dr Anita Harsh
241/3 Parwati Marg, Rajapark Jaipur INDIA