Title: Detection of large number of NS1+ Dengue Virus (DENV) cases at Lucknow, India during the years 2016 and 2017
Authors: AK Kapoor, Divya Singh, Reena Singh, Priyamvada Saxena
DOI: https://dx.doi.org/10.18535/jmscr/v6i1.10
Abstract
Large number of cases with dengue fever (n = 833) were reported in our lab from 30th June 2016 to 26th November 2016. Later, in subsequent year 173 patients with dengue fever were recorded. Diagnosis of dengue virus infection was confirmed by dengue NS1 antigen detection test using human serum samples. All the patients (n = 1006) were dengue NS1 positive (NS1+ ). Dengue-IgM antibody was also detected in sera of 86 patients. In addition, anti-IgG antibody test was positive in 12 patients. NS1+ patients were reported mainly from Gomtinagar, Indira nagar and Ajanta hospital, Alambagh areas. Results of CBC revealed leucopenia in 229 of 513 (45%) patients in year 2016 and in 37 of 90 (41%) patients in year 2017. Only 7 of 513 patients had leucocytosis in the year 2016. Severe thrombocytopenia was detected in 116 of 693 (13%) patients in the year 2016 while it was detected only in 14 of 127 (11%) patients in the year 2017. Development of herd immunity during 2016 outbreak of dengue fever might have resulted in serotype-specific neutralizing antibody formation and lower incidence of dengue fever in following year. Both thrombocytopenia and leucopenia appeared to contribute to severity of disease.
Keywords: Dengue virus leucopenia thrombocytopenia.
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