Title: Spirometric Assessment of Pulmonary Function in Non Smoker Patients of Coronary Artery Disease and/or Hypertension and Comparison with Healthy Subjects
Authors: Adrita Kar, Biswajit Majumder, Atin Dey
DOI: https://dx.doi.org/10.18535/jmscr/v5i11.42
Abstract
Coronary artery disease and hypertension are major health problems in today’s world. Recently lot of interest has been generated regarding the possible systemic and pulmonary effects of the pervasive low grade inflammation that is present in coronary artery disease and hypertension. Many studies have objectively demonstrated undisputable evidence of airflow limitation in a setting of CAD and hypertension accompanied by a low FEV1, FVC and FEV1/FVC ratio. In our study, we compared the spirometric indices of 100 patients of CAD and/or hypertension to healthy subjects. It was found that 25% of such patients suffered from undiagnosed airflow limitation as compared to only 2% in healthy patients. The difference was significant. Therefore we recommend that spirometric screening is an easy, non invasive and inexpensive tool to diagnose undetected obstructive airway disesase in such patients and treat the same.
References
- Zachariah JP, Vasan RS, D’Augustino RB. The burden of increasing worldwide cardiovascular disease. In, Fuster V.(Ed). Hurst’s The Heart, 13th New Delhi, McGraw Hill, 2011;24
- org[Internet]. New Delhi: South Asia Network Of Chronic Diseases;c2011. Available from http://www.sancd.org/factsheets
- Kotchen TA. Hypertensive vascular diseases. In, Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo j (eds). Harrison’s Principles of Internal Medicine, 18th edition, New York. Mc Graw Hill Companies. 2012;2414-16
- Chobanian AV, Bakris GL, Black GR, Cushman WC, Izzo DL. Seventh Report of the Joint national committee on prevention, detection, evaluation, and treatment of High Blood Pressure. JAMA 2003;289:2560-72
- Mohan S, Campbell N, Chockalingam A. Time to address hypertension in India. Indian J Med Res 2013;137:627-31.
- Global Strategy for the Diagnosis , Management and Prevention of COPD[Internet]. Global Initiative for Chronic Obstructive Lung Disease [GOLD];2014. Available from http://www.goldcopd.org/
- Hassan A, Ansari N,Parvez A, Beg M, Bhargava R. Understanding the relation between COPD and coronary artery disease. JIACM 2014;15:120-4
- Sunyer J, Ulrik CS. Level of FEV1 as a predictor of all cause and cardiovascular mortality; an effect beyond smoking and physical fitness? Eur Respir J2005;25:587-8.
- Canver CC, Nichols RD, Kroncke GM. Influence of age specific lung function on survival after coronary bypass. Ann Thorac Surg. 1998;66:144-7
- Higgins MW, Keller JB. Predictors of mortality in the adult population of Teumsch. Arch Environ Health 1970;21:418-24
- Stavem K, Aaser E, Sandvik L, Bjornholt J, Erikssen G. Lung function, smoking and mortality in a 26 year follow up of healthy middle aged males. Eur Resp J. 2005;4:618-25.
- Enright PL, Kronmal RA, Smith V. Reduced vital capacity in elderly persons with hypertension, coronary heart disease or left ventricular hypertrophy: the cardiovascular health study. Chest 1995;107:28-35
- Ahmed AM, Tarig EY, Muthana F. Prevalence of chronic obstructive pulmonary disease in patients with catheter diagnosed coronary artery disease. Ann Thorac Med 2009;4:91-2.
- Patil VC, Pujari BN, Patil HV, Munjal A, Agarwal V. Prevalence of obstructive airway disease by spirometric indices in non smoker subjects with IHD and hypertension. Lung India 2012;29:241-252
- Pramod V, Bhanu R. Pulmonary function tests in hypertensive patients. IOSR-JDMS 2015;14:6-9
- Yadav A, Singh S, Singh KP. Status of pulmonary function tests and diffusiuon capacities in coronary artery disease patients. AMIRJI 2014;1:1-5