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Category: Volume 05 Issue 11 November 2017
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Title: Role of Biofilms in the chronicity and resistance in patients of Chronic Rhinosinusitis: A Prospective study

Authors: Namit Kant Singh, Lakshmi Narayan Garg, Shubhranshu Shekhar, Naiya Rao, Anshul Singh

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i11.34

Abstract

The role of Biofilms in the disease process and chronicity of Rhinosinusitis has been evaluated and suggested by many researchers but its role in the resistance to antimicrobials and chronicity of the disease is still under evaluation. Hence taking intoconsideration the above fact a Prospective study was undertaken to evaluate the role of biofilms in the chronicity and resistance in patients of Chronic Rhinosinusitis.

Materials and Methods: Patients were divided into two groups cases (as per the Rhinosinusitis Task Force Criteria of 1993 and its amendment in 2006) and controls. Nasal swabs were taken and were sent for culture and sensitivity. The specimens in which growth of organism was identified were further subjected to test their ability to form biofilms.

Results: Methicillin Resistant Staphylococcus aureus (MRSA) was found to be the most common organism isolated, A higher percentage of biofilm forming organisms were present amongst the cases as compared to controls rendering a p-value of 0.00001124, which is highly significant, the isolates from cases were sensitive to higher order antibiotics as compared to controls and also showed a higher degree of antimicrobial resistance.

Conclusion: Through this study we conclude that there is a definite role of Biofilms in chronicity and antimicrobial resistance amongst organisms which are the causative agents of Chronic Rhinosinusitis.

Keywords: biofilms, chronic rhinosinusitis, staphylococcus aureus, antimicrobial resistance.

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Corresponding Author

Lakshmi Narayan Garg

Professor Department of E.N.T,

M.M.Institute of Medical Sciences and Research, Ambala, Haryana 13320

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