Title: Correlation between quality of sleep, depression, BODE Index and quality of life in COPD patients

Authors: Dr Aqsa Mujeeb (PT), Dr Shambhovi Mitra (PT), Dr Rajnish Gupta

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i11.27

Abstract

Background: One of the least studied symptoms of Chronic Obstructive pulmonary disease (COPD) are quality of sleep and Obstructive Sleep Apnea(OSA). The aim of this study was to find the correlations between qualities of sleep, depression, BODE Index and quality of life in COPD patients.

Materials and Methods: 52 stable COPD patients were recruited according to GOLD 2013 guidelines as per the inclusion and exclusion criteria. Hindi versions of four questionnaires were administered - The Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire 9 (PHQ 9) and the St. George Respiratory questionnaire (SGRQ) and the patients were assessed for quality of sleep, depression and quality of life respectively. 6 minute walk tests and Pulmonary function tests was performed as per American Thoracic Society (ATS) guidelines.

Results: In the sample of 52 patients there were 43 males and 9 females, with mean age 57.01(+/-9.27). All patients had affected quality of sleep and 5.76% indicative of OSA. There were significant correlations between the Pittsburgh Sleep Quality Index. Patient Health Questionnaire 9, the St. George Respiratory questionnaire and BODE Index (p value < or = 0.05).

Conclusion: The prevalence of affected quality of sleep is high in COPD and there is a significant correlation between quality of sleep, depression, BODE Index and quality of life in COPD patients.

References

  1. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. Updated 2013. Available from ; http:\\www.goldcopd.com.
  2. Sajal De, subjective assessment of quality of quality of sleep in chronic obstructive pulmonary disease patients and its relationship with associated depression, Lung India, vol – 29,issue 4, oct-dec 2012, 332-335
  3. Kochhar PH, Rajadhyaska SS, Suvarna VR for PRIMEMD Study Group. Translation and validation of brief patient health questionnaire against DSM IV as a tool to diagnose major depressive disorder in Indian patients. J Psotgrad Med 2007;53:102-7.
  4. Bhatia M, Prasad K, Pande RN, hindi validation of the Epworth Sleepiness scale, The Indian Journal of Sleep Medicine Year : 2006, Vol: 1, Issue : 4, 171-174
  5. Denial J Buysee et al, The Pittsburgh sleep quality index; A new instrument for psychiatric practice and research, Psychiatry research, vol 28, 193-213.
  6. LH Lindholm, The problem of uncontrolled hypertention, Journal of Human Hypertension (2002) 16, S3–S8
  7. Andrew L. Chesson et al, An American sleep association disorder review. The indications for polysomnography and related procedures. Sleep 20(6), 423 – 287.
  8. Clete A. Kushida et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005,
  9. Foteini Karachaliou, Konstantinos Kostikas, Chaido Pastaka, Konstantinos Kostikas, Prevalence of sleep-related symptoms in a primary care population - Their relation to asthma and COPD, DOI: 10.3132/pcrj.2007.00045.
  10. Lewis CA, Fergusson W, Eaton T, Zeng I, Kolbe J, isolated nocturnal desaturation in COPD – prevalence and impact on quality of life and sleep, Thorax 2009, 64, 133-8
  11. Nunes et al, impaired sleep reduces quality of life in chronic obstructive pulmonary disease, Lung 2009, 187, 159-63.
  12. Steven M Scharf et al, Sleep quality predicts quality of life in chronic obstru-ctive pulmonary disease, International Journal of Chronic Obstructive Pulmonary Disease 2011:6 1–12.
  13. Klar Yaggi, M.D., M.P.H., John Concato, M.D., M.P.H., Walter N. Kernan, M.D., Judith H. Lichtman, Ph.D., M.P.H.,Lawrence M. Brass, M.D., and Vahid Mohsenin, M.D. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death, N Engl J Med 2005;353:2034-41.
  14. H M Engleman, N J Douglas, Sleep ? 4: Sleepiness, cognitive function, and quality of life in obstructive sleep apnoea/ hypop-noea syndrome, Thorax 2004;59:618–622.
  15. M Medinas Amorós, C Mas-Tous, F Renom-Sotorra, M Rubí-Ponseti, MJ Centeno-Flores, MT Gorriz-Dolz, Health-related quality of life is associated with COPD severity: a comparison between the GOLD staging and the BODE index, Chronic Respiratory DiseaseMay 2009 6 no. 2 75-80.
  16. Nurhan Sarioglu et al, Relationship between BODE index, quality of life and inflammatory cytokines in COPD Patients, Multidisciplinary Respiratory Medicine 2010; 5(2):84-91.
  17. Prescott, T. Almdal}, K.L. Mikkelsenz, C.L. Tofteng, J. Vestbo§, P. Lange, Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study, Eur Respir J 2002; 20: 539–544.
  18. Jennifer A Cleland et al, Associations of depression and anxiety with gender, age, health-related quality of life and symptoms in primary care COPD patients, Family Practice—an international journal.
  19. Martijn A. Spruit et al Determinants of poor 6-min walking distance in patients with COPD: The ECLIPSE cohort, Respi-ratory Medicine (2010) 104, 849e857.
  20. Nicolia A Hanania et al. Determinants of Depression in the ECLIPSE Chronic Obstructive Pulmonary Disease Cohort, Am J Respir Crit Care Med Vol 183. pp 604–611, 2011.
  21. Sajal De, Prevalence of Depression in Stable Chronic Obstructive Pulmonary Disease, The Indian Journal of Chest Diseases & Allied Sciences, 2011;Vol.53, 36-39.
  22. Khaled Al-shair et al, Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD, Respiratory Medicine (2009) 103, 1572 – 1579

Corresponding Author

Aqsa Mujeeb

Warsi Appt, Plot No 458, Flat No 102,

Zakir Nagar (West), New Delhi – 110025

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.