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Category: Volume 05 Issue 09 September 2017
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Title: Effect of Daily versus Supervised Weekly Single Dose Oral Iron in Pregnant Women: Hematological Outcome

Authors: Dr Ruchi Saxena, Dr Karanveer Singh Solanki, Dr Madhu Patni (Bhat)

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i9.79

Abstract

Background: Anemia during pregnancy is an important risk factor of morbidity and mortality. Anemia especially if severe is directly or indirectly responsible for 40% of maternal deaths. Iron supplementation programmes are most practical short term approach to alleviate the problem. The present study aim to compare the effect of daily versus supervised single dose weekly oral iron supplementation, so that compliance is almost 100%, on haematological parameters in pregnant women.

Material & Methods: This is a prospective study of 200 women, attending antenatal clinic of department of obstetrics and gynecology, P.B.M. hospital and AG group of hospitals, S.P. medical college, Bikaner (Rajasthan). The women were randomly allocated in to two groups; one receiving daily and other receiving supervised single dose weekly iron supplementation. After taking informed consent, complete history and physical examination, all 200 pregnant women were subjected to routine antenatal investigations. Apart from routine antenatal investigation, detailed haematological work up was also done.

Results: In our study observed that difference of haemoglobin levels at baseline and at time of final sampling is find to be statistically insignificant (p>0.05). When the serum feeitin levels are compare between group A and group B, the difference at baseline is find to be statistically insignificant (p>0.05) whereas the difference in serum ferritin levels after 3 months oral iron supplementation is find to be statistically highly significant (p<0.05). In our study showed that haematological indices in group A and group B at the initiation of iron supplementation are comparable to each other. P value are not significant and after 3 month of iron supplementation there is no significance difference in haematological indices except in MCHC.

Conclusion: Our study concluded that weekly supervised iron therapy is cheaper, easy and more compliant & also has slightly better results than unsupervised daily iron therapy for prophylaxis of anemia.

Keywords: Iron supplementation, Anaemia, Hematological parameters, Pregnant.

 

References

  1. WHO/UNICEF. Indicators and strategies fir iron deficiency and anemia programmes. World Health Organization, Geneva. 1995.
  2. ICMR Evaluation of National Nutritional Anaemia Prophylaxis Programme. An ICMR Task Study. ICMR New Delhi 1989.
  3. Bhatt RV. Maternal Mortality in India. FOGSI, WHO study?. J Obstet Gynec of Ind 1997;47:201-14.
  4. Indian Council of Medical Research. ICMR, Task Force Study. New Delhi: Indian Council of Medical Research, 1989.
  5. Solomons NW, Pineda O, Viteri FE, Sandstead HH. Studies on the bioavailability of zinc in humans: mechanism of the intestinal interaction of non-heme iron and zinc. J Nutr 1986;116: 927-935.
  6. O’ Neil-Cutting MA, Crosby WH. Blocking of iron absorption by a preliminary oral dose of iron. Arch Intern Med 1987;147: 489-91.
  7. Book: Encyclopedia of Human Nutrition: Benzamin C., Lindsay A., Andrew P. Elsevier Academic Press. 2005.2nd:225.
  8. Mumtaz Z, Sahab S, Butt N et al. Daily iron supplementation is more effective than twice weekly iron supplementation in pregnant women in Pakistan in a randomized double blind clinical trial. The Journal of Nutrition, July 2007:2697-2702.
  9. Shankar H, Kumar N, Sandhir R et al. Weekly iron folic acid supplementation plays differential role in maintaining iron marker level in non anemic and anemic primigravida: a randomized controlled study. Saudi Journal of Biological Sciences, 2015:1-20.
  10. Ridwan E, Schultink W, Dillon D, Gross R. Effects of weekly iron supplementation on pregnant Indonesian women are similar to those of daily supplementation. Am J Clin Nutr 1996;63:884-890.
  11. Galloway R, Mc Guire J. Determinants of compliance with iron supplementation: supplies, side effects of psychology? Soc Sci Med 1994;39:381-390.
  12. Goshtasebi A, Alizadeh M. Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: A randomized control trial. East Mediterr Health J. June 2012;18(6):561-6.
  13. Godara S et al. To study compliance of antenatal women in relation to iron supplementation in routine antenatal clinic at tertiary health care centre. Journal of Drug Delivery and Therapeutics;2013: 3(3): 71-75.
  14. Sipra B et al. Effect of weekly iron supplementation on iron indices in pregnant women. Int J Med Res Health Sci. 2015;4(4):857-860.
  15. Khalid S et al. Effectiveness of weekly iron supplementation in anemia in pregnancy. Pakistan Journal of Pharmacology. Jan 2011;28 (1): 9-16.
  16. Farahnaz S et al. efficacy of daily versus intermittent administration of iron supplementation in anemia or blood indices during pregnancy. Caspian J Intern Med.2013;4(1):569-573.

Corresponding Author

Dr Ruchi Saxena

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