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Category: Volume 05 Issue 09 September 2017
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Title: Effect of Drotavarine Hydrochloride and A Combination of - Hyoscine–N-Butyl Bromide With Valethamate Bromide on the Duration of Active Phase of Labor - A Comparative Study

Authors: Surbhi Saini, Balwinder Kaur, Arvinder Kaur

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i9.74

Abstract

Labor, an important event, is marked by the fear of pain. Painless and short labor is desired. Obstetricians goal is, healthy neonate and mother. Methods used to shorten active phase of labor are welcomed. Prolonged labor causes high feto-maternal morbidity. Shortening of duration of labor, without jeopardizing feto- maternal interests is warranted,. Various methods tried to accelerate labor. Hyoscine-n-butyl bromide, scopolamine and Valethamate bromide widely studied. Present study conducted to compare effects of Drotavarine hydrochloride and combination of Hyoscine-N-butyl bromide plus Valethamate bromide on duration of active phase and their feto-materal side effects.  200 women divided into two groups 100 each.  Group A received Drotavarine hydrochloride 40mg I/M, 2 doses 2 hours apart(2nd if required). Group B given combination of Hyoscine-N-butyl bromide 40 mg and Valethamate bromide 16mg I/M, 2 doses 2 hours apart(2nd if required). 98% delivered vaginally. 2% (LSCS) in each group and excluded. Mean no. of doses 1.36±0.48 (Group A), 1.83±0.37 (Group B) p value <0.001 HS. Mean rate of dilatation (cms/hr) was more in Group A(3.81±1.52) than B (2.29±0.64) p value<0.001 HS. Mean Active phase was 112.70±53.09 mins in Group A and 171.44±57.24 min in B, p value<0.001 HS. Drug-delivery interval was 45.10±63.22 min (groupA) and 202.09±60.35 min (Group B) p value <0.001HS. No serious feto-maternal side effects. Drotavarine and combination drugs are safe to shorten the duration of active phase.

Keywords: Drotavarine,Valethamate, active phase. Dilatation. 

 

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Corresponding Author

Balwinder Kaur

Associate Professor

360 North Avenue, Bhadson Road Patiala Punjab India, 147001

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