Title: Viper Bite Envenomation- A Clinical study searching for Neurological Manifestations

Authors: Ajith S.N, Jacob Antony, Sajan Christopher

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.111

Abstract

Background: Viper bite envenomation is prevalent in northern Kerala. Its clinical manifestation is varied. Haematological features dominate its clinical presentation. This study focuses on its neurological effects.

Methods: We conducted a prospective study involving 52 patients in Kozhikode district with viper bite envenomation of which 35 were bitten by Russell’s viper and the rest 17 by saw-scaled viper. All cases were subjected to detailed clinical evaluation with emphesis to local effects, hemorrhagic and local manifestations. Relevant investigations were done with special tests like neostigmin test in selected cases

Results: All patients had signs of local envenomation with local serosanginous blister formation in 8% and regional lymphadenopathy in 24%. Paralytic symptoms developed only in patients with Russell’s viper envenomation. These were ptosis in 28%, external ophthalmoplegia in 20%, dysarthria (8%) and dysphagia (2.8%)

Conclusions: Neurological manifestations do occur after viper bite envenomation. It is observed only after Russell’s viper bite. Ptosis and external ophthalmoplegia are the commonly seen manifestations, dysarthria and dysphagia occur in moderate to severe envenomation.

Keywords: Viper, Envenomation, neurological manifestations.

References

1.      Ariaratnam CA, Sheriff MH, Arambepola C, Theakston RD, Warrell DA. Syndromic approach to treatment of snakebite in Sri Lanka based on results of a prospective national hospital-based survey of patients envenomed by identified snakes. Am J Trop Med Hyg. 2009 Oct;81(4):725-31.

2.      Bhat RN. Viperine snakebite poisoning in Jammu. J Indian Med Assoc. 1974 Dec 16; 63(12): 383-92.

3.      Bücherl W, Buckley EE & Deulofeu V (eds) . Venomous animals and their venoms. Vols 1 and 2. Academic Press, New York. (1968, 1971)

4.      Dayal M, Prakash S, Verma PK, Pawar M. Neurotoxin envenomation mimicking brain death in a child: A case report and review of literature. Indian J Anaesth. 2014 Jul;58(4):458-60.

5.      Directorate General of Health Services Ministry of Health and Family Welfare Government of India. National Snakebite Management Protocol [internet]. New Delhi;2009. Available from http://164.100.130.11:8091/ nationalsnakebitemanagementprotocol.pdf

6.      Gans C,Gans KA. eds. Biology of the reptilia. Vol 8. London: Academic Press;1978.782 p.

7.      Gawarammana I, Mendis S, Jeganathan K. Acute ischemic strokes due to bites by Daboia russelii in Sri Lanka - first authenticated case series. Toxicon. 2009;54:421-8.

8.      Gopalakrishnakone P, Chou LM . Snakes of medical importance (Asia-Pacific Region).Singapore: National University of Singapore Press;1990.

9.      Ghose A, Amin MR, Haq MA, Islam A, Chowdhury FR, Miah T, et al. Russell’s Viper (Daboia russelii): A newly recognized cause of neuro-myo-renal toxic envenomation in Bangladesh. In Proceeding 18th World Congress of the International Society on Toxinology ; 2015 Sept 25-30; oxford (United Kingdom) ; c2015. P. 91.

10.  Harvey AL. Snake toxins. New York: Pergamon Press, 1991.

11.  Jayanthi GP, Gowda TV Geographical variation in India in the composition and lethal potency of Russell's viper (Vipera russelli) venom. Toxicon. 1988;26(3):257-64.

12.  Kochar DK, Tanwar PD, Norris RL, Sabir M, Nayak KC, Agrawal TD, et al. Rediscovery of severe saw-scaled viper (Echis sochureki) envenoming in the Thar desert region of Rajasthan, India. Wilderness Environ Med. 2007;18(2):75-85.

13.  Prasad NB, Uma B, Bhatt SK, Gowda VT. Comparative characterisation of Russell's viper (Daboia/Vipera russelli) venoms from different regions of the Indian peninsula. Biochim Biophys Acta. 1999 Aug 5;1428(2-3):121-36.

14.  Warrell DA. Snakebite. Lancet. 2010 Jan 2; 375(9708): 77-88.

15.  Warrell DA, Arnett C. The importance of bites by the saw-scaled or carpet viper (Echis carinatus). Epidemiological studies in Nigeria and a review of the world literature. Acta Tropica Basel, 1976; 33: 307-41.

Warrell DA. Geographical and intraspecies variation in the clinical manifestations of envenoming by snakes. In Thorpe RS, Wüster W, Malhotra A, editors: Venomous snakes: Ecology, evolution and snakebite. Oxford:Clarendon Press;1997.p.189-203.

Corresponding Author

Jacob Antony

Additional Professor, Dept of Medicine,

Government Medical College, Thiruvananthapuram, Kerala, India

Phone (Mobile) No.: +919447452672, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.