Title: A Study on MRSA Isolates in MCH Microbiology Lab, Medical College Hospital, Thiruvanantapuram
Authors: Dr S.Manjusree, Dr Ramani Bai.J.T, Dr Girish Kumar.C
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.61
Abstract
Methicillin Resistant Staphylococcus aureus (MRSA) were noticed in 1961 and they developed into a Health-care associated organism throughout the world. Recently the appearance of endemic Community- acquired MRSA has been reported. Infections due to community acquired MRSA are recent world wide phenomenon. This study was undertaken to compare CA-MRSA and HA-MRSA isolates on the basis of their genotyping results, clinical presentations and antibiotic susceptibilitiy pattern.
Method
Study design: Descriptive study.
Study Setting: Central Microbiology laboratory, Govt. Medical College, Thiruvananthapuram.
Sample size: 161 isolates of Methicillin Resistant Staphylococcus aureus.
Study period: 1 year.
Results: The proportion of HA-MRSA is 94(58%) and CA-MRSA 67(42%) among 161 MRSA isolates. A male preponderance is observed in both types of MRSA. The commonest clinical presentation of HA-MRSA is cellulitis ie,32(34.04%) ,followed by post operative wound infection ie,27 (28.72%). The commonest clinical presentation of CA-MRSA is abscess ie,27(40%), followed by post traumatic wound infection ie,14 (21% ) . Extremes of age, history of recent hospitalization in past I year, history of surgery in the past and Type 2 Diabetes Mellitus are the risk factors observed in case of HA-MRSA. CA-MRSA isolates show lower resistance rate towards Trimethoprim –Sulfamethoxazole 15(22.3%) than 27,(28.72%) of HA-MRSA. Resistance rates of Gentamicin were high in both CA- MRSA and HA-MRSA, ie 92.5% and 93.6% respectively. CA-MRSA showed more resistance to Amikacin 28(41.79%) and HA-MRSA 0(21.27%).CA-MRSA showed resistance to Ciprofloxacin for 65 strains (97%) and HA- MRSA to 62 strains (65.9%). Both types of MRSA showed a low and similar resistance rate of Tetracycline ie, 10.44% CA and 9.57% HA-MRSA respectively. Lower rate of Clindamycin resistance was shown by both CA-MRSA and HA-MRSA ie, 1 (1.49%) and 6 (6.38%) respectively. All 94 isolates of HA-MRSA and 67 isolates of CA-MRSA were uniformly sensitive to Vancomycin , Linezold and Rifampicin.
Keywords: CA-MRSA,HA-MRSA.
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