Title: Role of Serum PSA in Diagnosis of Prostate Cancer with Histopathological Correlation and Predictive Value of Serum PSA in Early Detection of Prostate Cancer
Authors: Avinash Parshuram Dhok, Amol Madanlal Lahoti, Sandeep Dhote, Abhijit K Taori, Sarang Ingole, Prashant N. Mudaliar, Vikrant Bhende, Nihar Umakant Chandak
DOI: https://dx.doi.org/10.18535/jmscr/v5i7.16
Abstract
Prostate cancer is second leading cause of death in cancer related mortality after lung cancer i.e. mortality of prostate cancer is 6.6% and that of lung cancer is 23.6%. But 5 year prevalence of prostate cancer is highest i.e. 25.5. So Prostate cancer (PC) is an important medical and socio-economical problem due to its increasing incidence among the male populationand It is becoming an enormous health care burden and its early diagnosis is crucial for a successful treatment which ultimately will prolong and improve the quality of life. Widespread use of serum prostate specific antigen (PSA) level screening has dramatically increased the diagnosis of even small, early-stage prostate cancer lesions.
Aims: Role of serum PSA level in diagnosis of prostate cancer with its histopathological correlation.
Methods and Material: The study is a diagnostic cross-sectional study and Patients were informed about the nature and objective of the study and written informed consent was taken before recruiting them into the study after approval of the Institutional Ethics Committee.
Results: 1) Use of serum prostate specific antigen (PSA) level measurement increases the diagnostic accuracy of even small, early-stage prostate cancer lesions.
2) PSA level is a strong indicator of stage and prognosis.
Conclusions: The findings of study indicates that serial measurement of serum PSA level help in diagnosis of even small and early-stage prostate cancer. PSA level is indirect indicator of stage and prognosis of prostate cancer. Screening is advised in male population older than 50 years.
Keywords: prostate specific antigen, Prostate cancer, early diagnosis, screening
Key Messages: Screening male adults over 50 years of age with Prostatic specific antigen (PSA) can help diagnose prostate cancer early so as to prevent complications arising out of late diagnosis. Serum PSA is cost effective, easily available and non-invasive screening test.
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