Title: Gastric Malignant Peripheral Nerve Sheath Tumor – A Rare Mesenchymal Tumor in the Era of C-Kit

Authors: Prof Subbiah Shanmugam MS, MCh, Prof Gopu Govindasamy MS, MCh, Dr Syed Afroze Hussain MS, MCh, Dr Prasanna Srinivasa Rao H. MS

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i7.13

Abstract

Malignant tumors of stomach other than carcinomas are less common. The more frequent of these are lymphomas and Gastrointestinal stromal tumors. A malignant peripheral nerve sheath tumor (MPNST) of stomach is extremely rare and only five cases have been reported in literature so far. Here we report a case of a Gastric malignant peripheral nerve sheath tumor in a patient of neurofibromatosis.

Keywords: Gastric MPNST, Malignant Peripheral nerve sheath tumor, Stomach Carcinoma, Neurofibromatosis

References

1.      Grobmyer SR, Reith JD, Shahlaee A, Bush CH, Hochwald SN. Malignant Peripheral Nerve Sheath Tumor: molecular pathogen-nesis and current management considerations. J Surg Oncol. 2008;97(4): 340–9.doi: 10.1002/jso.20971. [PubMed: 18286466].

2.      Perrin RG, Guha A. Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 2004;15(2):203–16. doi: 10.1016/-j.nec.2004.02.004.[PubMed: 15177319].

3.      Thway K, Fisher C. Malignant peripheral nerve sheath tumor: pathology and genetics. Ann Diagn Pathol. 2014;18(2):109–16. doi:10.1016/j.anndiagpath.2013.10.007. [PubMed: 24418643].

4.      Zou C, Smith KD, Liu J, Lahat G, Myers S,Wang WL, et al. Clinical, pathological and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg. 2009;249(6):1014–22. doi:10.1097/SLA.0b013e3181a77e9a. [PubMed: 19474676].

5.      Fan Q, Yang J, Wang G. Clinical and molecular prognostic predictors of malignant peripheral nerve sheath tumor. Clin Transl Oncol.2014;16(2):191–9. doi: 10.1007/s12094-013-1061-x. [PubMed: 23749326].

6.      Carli M, Ferrari A, Mattke A, Zanetti I, Casanova M, Bisogno G, et al. Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. J Clin Oncol. 2005;23 (33):8422-30. [DOI] [PubMed]

7.      Stasik CJ, Tawfik O. Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differentiation (Malignant Triton Tumor) Arch Pathol Lab Med. 2006;130:1878–1881. [PubMed]

8.      Chung K, Han Y, Kim J, Ahn SH, Ju SG, Jung SH, et al. The first private-hospital based proton therapy center in Korea; status of the Proton Therapy Center at Samsung Medical Center. Radiat Oncol J. 2015;33(4):337-43. [DOI] [PubMed]

9.      Cuneo KC, Riedel RF, Dodd LG, Harpole DH, Kirsch DG. Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy. J Clin Oncol. 2012;30(28):291-3. [DOI] [PubMed]

10.  Everett M, Gutman H. Surgical management of gastrointestinal stromal tumors: analysis of outcome with respect to surgical margins and technique. J Surg Oncol. 2008;98(8):588-93. [DOI] [PubMed]

11.  Danid NL, Hiroko O, Otmar DW, WHO classification of tumors—pathology and genetics of tumors of the nervous system; 4th Edition. WHO. 2007:160.

12.  N R Bees, C S Ng, C Dicks-Mireaux, and E M Kiely. Gastric malignant schwannoma in a child. British journal of Radiology 1997 vol 7

13.  Loffeld RJ1, Balk TG, Oomen JL, van der Putten AB. Eur J Gastroenterol Hepatol. 1998 Feb;10(2):159-62. Upper gastrointestinal bleeding due to a malignant Schwannoma of the stomach.

14.  Akira Watanabe,a,* Hitoshi Ojima,b  Shigemasa Suzuki,a Yasushi Mochida,b  Isao Hirayama,b Yasuo Hosouchi An Individual with Gastric Schwannoma with Pathologically Malignant Potential Surviving Two Years after Laparoscopy-Assisted Partial Gastrectomy. Case Rep Gastroenterol. 2011 May-Aug; 5(2): 502–507. Published online 2011 Aug 30. doi:  10.1159/000331561PMCID: PMC3180670

15.  Masashi Takemura,1 Kayo Yoshida,corresponding author2 Mamiko Takii,2 Katsunobu Sakurai,2  and Akishige Kanazawa2. Gastric malignant schwannoma presenting with upper gastrointestinal bleeding: a case report. J Med Case Reports. 2012; 6: 37.Published online 2012 Jan 25. doi:  10.1186/1752-1947-6-37PMCID: PMC3292804

16.  Takemura M, Yoshida K, Takii M, Sakurai K, Kanazawa A. Gastric malignant schwannoma presenting with upper gastrointestinal bleeding: a case report. Journal of Medical Case Reports. 2012;6:37. doi:10.1186/1752-1947-6-37.

Corresponding Author

Prof Subbiah Shanmugam MS MCh

Address: No.110, Courtyard, Ramnagar, 3rd Main street,

Nanganallur, Chennai, India, Pincode – 600061

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