Title: Treatment Outcome of Tuberculosis in Children Put Under Directly Observed Therapy Short Course in a Tertiary Care Hospital- A Retrospective Cross Sectional Study
Authors: Aaliya Wani, Danish Zahoor, Suhail Manzoor Shah, Yasir Wani, Ishfaq Ahmad Dar Showkat Ali Laloo, Saleem -ur -Rehman
DOI: https://dx.doi.org/10.18535/jmscr/v5i5.199
Abstract
Tuberculosis in childhood is a marker for transmission of disease in the community. Data regarding the treatment outcome of childhood tuberculosis is limited. We retrospectively analyzed the disease course and treatment outcome of patients registered under RNTCP in a tertiary care hospital. Children under the age of 15 years registered for treatment were included in the study. Besides analyzing the demographic data, clinical profile, categorization of patients in to new cases and previously treated cases, and treatment outcome were determined. Of the 121 cases, 51 were extra pulmonary, 32 were smear positive pulmonary tuberculosis while 15 were smear negative pulmonary tuberculosis. Childhood TB accounts for 12.06% of the total TB cases. Median age was 13 years. 87 (88.76%) completed treatment, 4 (4.08%) defaulted, 3 died while 2 did not turn up for treatment after diagnosis of tuberculosis in them. As the nature of childhood tuberculosis is paucibacillary, diagnosis is challenging especially with high proportion of extrapulmonary cases.
Keywords: Pediatric tuberculosis, pulmonary TB, extra-pulmonary TB, outcome.
References
1. Global tuberculosis control—epidemic-ology, strategy, financing. WHO Report 2009. http://www.who.int/tb/publicati-ons/global_report/2009/en/index.html. 31 August 2009.
2. Chakraborty AK. Prevalence and incidence of tuberculosis infection and disease in India. Geneva: WHO; 1997 (WHO/TB/97.231).
3. Swaminathan S and Rekha B. Pediatric tuberculosis: global overview and challenges. Clin Infect Dis. 2010;50: S184–S194.
4. Perez-Velez CM and Marais BJ. Tuberculosis in children. New Engl J Med. 2012; 367:348–361.
5. New Delhi: Central TB division, Ministry family of health and family welfare, Nirmal Bhawan; 2009. Mar, TB India 2009, RNTCP status report; pp. 1–5.
6. Marais BJ, Hesseling AC, Gie RP, Schaaf HS, and Beyers N. The burden of childhood tuberculosis and the accuracy of community-based surveillance data. Int J Tuber Lung Dis. 2006; 10:259–263.
7. Central TB Division, Directorate General Health Services, Ministry of Health and Family Welfare, Government of India (2012) Revised National Tuberculosis Control Programme training manual for culture and drug susceptibility testing.
8. Nelson LJ, Wells CD: Global epidemiology of childhood tuberculosis. Int J Tuberc Lung Dis 2004, 8(5):636–647.
9. Dereje Hailu, Woldaregay Erku Abegaz and Mulugeta Belay. Childhood tuberculosis and its treatment outcomes in Addis Ababa: a 5-years retrospective study. BMC pediatrics. 2014;14:61-66.
10. Aketi L, Kashongwe Z, Kinsiona C, Fueza SB, Kokolomami J, Bolie G et al. Childhood Tuberculosis in a Sub-Saharan Tertiary Facility: Epidemiology and Factors Associated with Treatment Outcome. PLoS ONE 2016; 11(4): e0153914.
11. Jain SK, Ordonez A, Kinikar A, Gupte N, Thakar M, Mave V, et al. Pediatric Tuberculosis in Young Children in India: A Prospective Study. BioMed Research International. 2013;783698 doi: 10.1155/2013/783698
12. Berman S, Kibel P B, Fourie P B, Strebel P M. Childhood tuberculosis and tuberculous meningitis: high incidence rates in the Western Cape of South Africa. Tubercle 1992; 73: 349–355.