Title: Epidemiological Study of Opportunistic Infections in HIV Sero Positive Patients in South India

Authors: Eppa Harikrishna, P.Durga, Dr D.Sudher Kumar, Dr P.Kishore,  V. Chandrashekar

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i5.182

Abstract

Introduction: Human Immunodeficiency Virus leads (HIV) to Acquired Immune Deficiency Syndrome(AIDS) and opportunistic infections (OI’s) and causes increased morbidity and mortality of such patients which considerable affects quality of people living with HIV/AIDS.  We therefore conducted this study to document the prevailing prevalence of opportunistic infections after initiation of highly active antiretroviral therapy in a south Indian state.

Methods and Materials: It is an observational study has been conducted in a tertiary Hospital, located in Warangal city of Telangana state. A total of 500 cases were collected during the study period of 6 months i.e. jan2016 to june 2016, of them 197 cases were identified with opportunistic infections.

Results: During this period a total of 500 cases were collected. Of them, 197 cases were presented with minimum of single opportunistic infection. Oral candidiasis and pulmonary tuberculosis were found to be more prevalent among all the conditions i.e, 25.64% and 24.78% respectively followed by peripheral neuropathy (6.41%), herpes zoster (5.98%) and upper respiratory tract infection (5.98%), diarrhea (5.56%), urinary tract infection (4.27%), pyrexia (4.70%,), pneumocystis pneumonia (3.85%). 

Conclusion: This study is the first ever on cumulative reported data study ever on opportunistic infections among HIV/AIDS patients on active care from city of Warangal showing the real-time distribution from southern India. This will serve as a matrix for future evaluation. 

Key words: HIV/AIDS, Opportunistic infections, Tuberculosis, Candidiasis, CD4 count.

References

1.      WHO. Facts on HIV/AIDS updated November 2016.

http://www.who.int/features/factfiles/hiv/en/

2.      UNAIDS. Global report: UNAIDS report on the global AIDS 2015. Geneva: Joint United Nations Programme on HIV/AIDS (UNAIDS), 2015. http://aidsinfo.unaids.org/#data-details

3.      Simoes EAF, Babu GP, John TJ, et al. Evidence for HTLV-3 infection in prostitutes in Tamil Nadu(India). India J Med Res 1987;85:335-8.

4.      Solomon S, Anuradha S, Ganapathy M et al. Sentinel surveillance of HIV-1 infection in Tamilnadu, India. Int J STD AIDS 1994:5:445-6.2. Solomon S, Anuradha S, Ganapathy M, et al. Sentinel surveillance of HIV-1 infection in Tamilnadu, India. Int J STD AIDS 1994; 5:445–6.

5.      Annual report_NACO_2014-15.National AIDS Control Organisation, Ministry of Health and Family Welfare, Government of India. Available at:

http://www.naco.gov.in/upload/2015%20MSLNS/Annual%20report%20_NACO_2014-                 15.pdf.

6.      Srirangaraj S, Venkatesha D. Opportunistic infections in relation to antiretroviral status among AIDS patients from south India. Indian J Med Microbiol 2011;29:395-400.

Rohit Goel et.al, “Clinical Profile and Response to First-Line ARV in HIV Patients from Eastern UP and Bihar: A Retrospective Study”. The Journal of the Association of Physicians of India 

8.      Ripunjoy Sonowal , Ajit Goswami. Opportunistic Infections in HIV Seropositive Patients: A Study in a Tertiary Hospital in Assam, Northeast India. Sch. J. App. Med. Sci., 2015; 3(1C):206-208.

9.      Jayant D Deshande et.al, “Clinico-epidemiological  profile if HIV patients attending ART centre in rural Western Maharashtra, India”. South East Asia Journal of Public Health 2012;2(2):16-21.

10.  M. H. Usmani, Rifat Qureishi, Rakesh Patel, Praveen Kumar M. Clinical Spectrum of Opportunistic Infections in HIV Positive Patients. Journal of Evolution of Medical and Dental Sciences 2015; Vol. 4, Issue 24, March 23; Page: 4076-4085.

11.  Gorantla M, Yadav K, Malhotra V. Spectrum of Chief Complaints and Opportunistic Infections among HIV Seropositive Patients Attending A Community Care Center in Nalgonda District, Andhra Pradesh. . IJHSR. (2015), 5(4): 288-291.

12.  Weerawat Manosuthi et.al, “Incidence and risk factors of major opportunistic infections after initiation of antiretroviral therapy among advanced HIV-infected patients in a resource-limited setting” The British Infection Society (November 2007) Volume 55, Issue 5, Pages 464–469.

Corresponding Author

Dr V.Chandrashekar M.D,

Principal & HOD Department of Medicine, KMC/MGM Hospital, Warangal

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Phone no.: 9346950050