Title: Systemic Lupus Erythematosus (SLE) with Sickle Cell Disease (SCD)-A Rare Case Series

Authors: Ali Nasreen, Agarwalla Kumar Sunil, Muhamed Shabeer, Pattanaik Biswajit, Satapathy Shreya Jagat, Patro Debasis, Tudu Laxmipriya

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i5.168

Abstract

SLE and SCD are relatively common disorders especially in India and Africa but the combination of connective tissue disease particularly SLE with SCD in a same individual appears to be rare. The actual incidence is not known because most of the published studies are case reports. Only 40 similar cases have been reported in the literature over the past 50 years. Because of the substantial overlap between the clinical features of these disorders, a clinical diagnosis of SLE in patients with SCD is difficult to establish.

Here, we report 2 cases presenting with musculoskeletal and renal complications with fever to the paediatric casualty of MKCG. The complications were initially thought due to SCD with sepsis but when there was no improvement after routine management of SCD, immunological markers were tested which came to be positive. Thus confirming the diagnosis of SLE with SCD.

Keywords: Connective tissue disease, Systemic lupus erythematosus (SLE), Sickle cell disease (SCD), immunological markers.

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Corresponding Author

Ali Nasreen

Junior Resident, Paediatric Department

MKCG Medical College Berhampur