Title: Clinicopathological Profile & Correlation of Tumor Size with Nodal Status in Oral Cavity Cancers: An AHRCC Experience

Authors: Samantaray Sagarika, Pattanayak Lucy, Panda Niharika, Pathy Pramod, Panda Sanjoy, Mohanty Lity

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i5.92

Abstract

Head and Neck Squamous Cell Carcinomas are the most common cancers in India and the sixth most common worldwide. Oral Cavity cancers are most predominant malignancies in Head and Neck Cancers. Tumor size and extent of invasion is an important risk factor for nodal metastases, local recurrence and survival. The clinicopathological profile and correlation between the tumor size and nodal metastases in 235 patients of oral cavity cancers attending AH Regional Cancer Centre from January 2016 to January 2017 was analysed. All 235 patients were histopthologically proven squamous cell carcinoma of the oral cavity. The data base included age, sex, addictions, site, type of surgery and histopathogical details. The data of the primary tumor included size, differentiation, grade, depth of invasion, perineural and lymphovascular invasion.For the neck, the data included presence of metastases, size and number of involved nodes and extracapsular extension.  A significant correlation between T stage and N stage was observed in the study. The primary tumor size is important in deciding management of the neck and volumetric assessment of tumor size along with thickness will help us to better define the nodal spread.

Keywords:  Tumor size, Node, Oral Cavity, squamous cell carcinoma.

References

1.      Shibuya K, Mathers CD,Boschi-Pinto C,et al. Global and regional estimates of cancer mortality and incidence by site; II. results for the global burden of disease 2000.BMC Cancer 2002;2:37.

2.      Varshitha A,prevalence of Oral Cancer in India, J.Pharm Sci & Res. Vol 7(10), 2015,845-48.

3.      Cerezo L,Millan I,Torre A, Aragon G, Otero J. Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer: a multivariate study of 492 cases. Cancer 1992; 69: 1224-34.

4.      Moore C, Flynn MB, Greenberg RA. Evaluation of size in prognosis of oral cancer.Cancer.1986;58: 158-62

5.      Chen TC, Wang CP, Ko JY, Yang TL,Hsu CW,Yeh KA et al. The impact of perineural invasion and/or lymphovascular invasion on the survival of early stage oral squamous cell carcinoma patients. Ann Surg Oncol,2013;20:2388-95

6.      Patel VA, Alastair LM, Fred R, et al. Advanced stage of head and neck cancer at a tertiary care county hospital. Laryngoscope 2006; 116(8): 1473-7

7.      Ramachandra NB. The Hierarchy of Oral Cancer in India.Int J of Head and Neck Surg 2012;3(3):143-46

8.      R Shenoi, V Devshukhkar, Chaudhuri, BK Sharma, SB Sapre, A Chikhale. Demographic and Clinical profile of oral squamous cell carcinoma patients: A retrospective study. Indian Journal of Cancer, 2012;49:21-6.

9.      D’Souza O,Hasan S, Chary G, et al. Cervical metastasis in head and neck malignancy- a clinical/ultrasonographic/ histopthological comparative study. Indian Journal of ORL 2004;55(2):90-3.

10.  Akmansu SH, Korkmaz H, Dursum E,et al. Clinical and histopthological indicators of neck node metastasis in laryngeal carcinoma. Tr J of Med Sci1999;29:313-7.

11.  Pinilla M, Gonzale FM, Cortizo L, et al. Management of N0 neck in laryngeal carcinoma: impact on patient’s survival. The Journal of Laryngology and Otology 2003;117(1):63-6.

12.  Shah JP, Candela FC, Poddar AK. The patterns of cervical lymph node metastases from squamous cell carcinoma of the oral cavity. Cancer 1990;66:109-13

13.  O’ Brien CJ, Lauer CS, Fredricks S, Cliffor AR,Macneil EB, Baagia JS, Koulmandan C: Tumor thickness influences prognosis of T1 and T2 oral cavity cancer- but what thickness? Head Neck,25:935-945,2003.

14.  Ayas B, Saleem K, Azim W, Shaikh A: A clinicopathological study of oral cancers. Biomedica 27: 29-32,2011.

Corresponding Author

Dr Lucy Pattanayak

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