Title: A Study of Different Hematological Parameters in Malaria

Authors: Joshi Hetal J., Sapre Jyoti P

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i5.46

Abstract

Aims: To study an alteration in hematological parameters in malaria.

Settings and Design: This is a prospective study conducted at Central Diagnostic Laboratory attached to Shree Krishna Hospital, Karamsad. All the smears positive for malaria cases, diagnosed at Pathology Laboratory were selected and studied for hematological changes.

Methods and Material: According to Proforma, detailed history regarding age, sex, nature and duration of illness is taken.  Venous blood in EDTA vaccutainer was collected from patient for diagnosis of malaria and hematological study before starting anti-malarial treatment.

Results: Out of 51 malaria positive patients, 41(80.3%) patients had P.vivax infection while 10 (19.6%) were infected with P.falciparum. Anemia, Thrombocytopenia and leucopenia were observed in 25 (49.01%), 48 (94.11%)  and 9  (17.64%) patients respectively. 

Conclusions: Species variation is seen in altered hematological parameters. Anemia and thrombocytopenia were more severe with p.falciparum infection while mild to moderate leucopenia was observed in p.vivax infection and it has no relation with p.vivax infection.

Keywords: Malaria, P.falciparum, P.vivax.

References

1.      “Malaria Fact sheet N 94’’ WHO. March 2014. Retrived 28 Aug 2014.

2.      Taylor-Robinson AW. Immunoregulation of malarial infection: balancing the vices and virtues. Int J Parasitol 1998 Jan;28(1):135-148.

3.      Das LK, Pan SP. Clinical manifestation of severe form of P.falciparum malaria in Koraput district of Orissa state, India. J Vector Borne Dis 2006;43:104-143.

4.      Kakar A,   Bhoi S,   Prakash V,   Kakar S. Profound   thrombocytopenia in plasmodium vivax malaria. Diagn Microbial Infect Dis. 1999; 35:243-44.

5.      Niazi GA. Hematological aspect of malaria in a population   based hospital Saudi Arabia. J Egypt Soc Parasite 1995; 25:787-93.

6.      Sen R, Tewari AD, Sehgal PK, Singh U, Sikka R, Sen J. Clinico-haematological profile in acute and chronic P.falciparum malaria in children. J Com Dis. 1994; 26:31-38.

7.      Rojanasthien S, Surakamolleart V, Boonpucknavig S, Isarangkura P. Hematological and coagulation studies in malaria. J Med Assoc Thai 1992; 75 Supl 1:190-194.

8.      Facer CA. Hematological aspects of malaria, In: Infection and Hematology. Oxford: Butterworth Heinmann Ltd., 1994. P. 259-94

9.      Perrin LH, Mackey LJ, Miescher PA. The hematology of malaria in man. Semin Hematol 1982 Apr;19(2):70-82.

10.  Dacie, S.J and Lewis, S.M.: Reference ranges and normal values, Practical Hematology, 10th edition, U.K., Churchill Livingstone Pub., 14-17 (2006).

11.  Ranjini CY, Roopa Murgod et al. comparison of hematological parameters between     Vivax and Falciparum malaria. Int J Pharm Bio Sci 2012 Oct; 3(4): (B) 1120 – 1128.

12.  Sethi Bhavna, Parasitemia and Hematological Alterations in Malaria: A Study from the Highly Affected Zones.

13.  Hematological changes in malaria: A comparative study, Dr Shamim Akhtar;  Agravat AH, Dhruva GA., Hematological changes in patients of malaria. J Cell Tissue Research, 10(3):2325-2329, (2010).

14.  Saleem Ahmed Khan, Waqar Ali et al. Platelet count in malaria. Pak J Pathol 86 2008; 19(3): 86-88.

15.  Horstmann R.D., M.Dietrich, U.Bienzle and H. Rasche,2005. Malaria induced thrombocytopenia. Annals of Hematol;42(3):157-64.

16.  Makkar RPS, Mukhopadhyay S, Monga A, Gupta A. Plasmodium vivax malaria      presenting with severe thrombocytopenia. Braz J Infect Dis.2002; 6:263-65.

17.  Faseela T.S, Ronald A. Roche, Anita K.B., Chaitra S Malli, Yashwanth Rai.Diagnostic  value of Platelet Count in Malaria. Journal of Clinical and Diagnostic Research. 2011 June, Vol-5(3): 464-466.

18.  White Blood Cell Counts and Malaria, F. Ellis McKenzie

19.  Dr. Kinjal Mendapara, Journal of Hematological Profile in Malaria patients coming to a Tertiary Care Center in Central Gujarat 2012 June, Page no. 12-13. 

20.  Tangpukdee N, Duangdee C, Wilairatana P, Krudsood S. Malaria diagnosis: a brief review. Korean J Parasitol 2009 Jun;47 (2):93-102.

21.  Koltas IS, Demirhindi H, Hazar S, Ozcan K. Supportive presumptive diagnosis of Plasmodium vivax malaria. Thrombocy-topenia and red cell distribution width. Saudi Med J 2007 Apr; 28(4):535-539.

22.  Dr. Kinjal Mendapara, Journal of Hematological Profile in Malaria patients coming to a Tertiary Care Center in Central Gujarat 2012 June, Page no. 12-13.

Corresponding Author

Dr Hetal J Joshi

Address: Ashish Hospital, Sherpura, Sardar Chowk, Petlad-388420.District: Anand Gujarat India

Phone numbers: 91 8156072400, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.