Title: Correlation between Glycosylated Haemoglobin (HbA1c) and Urinary Microalbumin with Complications of Diabetes
Authors: Dr Mayank Gupta, Dr Jagat Pal Singh
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.193
Abstract
Background: Diabetes complications are the major reason for the mortality in type 2 diabetes mellitus (T2DM). The biochemical parameters play an important role in the prediction of micro and macrovascular complications in diabetes mellitus.
Aims and Objectives: To investigate the role of biochemical markers such as serum creatinine, glycosylated haemoglobin (HbA1c) and microalbuminuria in the prediction of microvascular complications in patients with T2DM.
Materials and Methods: Hundred T2DM patients with diabetic nephropathy were studied at JAH and groups of hospital from May 2014 to November 2015 for their fasting blood sugar (FBG), post prandial blood glucose (PPBG), HbA1c, serum creatinine and microalbuminuria levels and they were also correlated with other diabetic complications. Results were categorized based on the presence or absence of the microvascular complications. All the analysis was performed using IBM SPSS Ver. 20. Significance is assessed at 5 % level of significance.
Results: Male preponderance (58.67%) was observed with mean age of cohort being 52.4±15.2 years. Increased micturation frequency (48%) was the mostly recorded presenting symptoms. Mean HbA1c, duration of diabetes, blood pressure, microalbuminuria and serum creatinine was 9.03±2.1%, 9.37 ±5.96 years, 132±22.4/84±12.5 mmHg, 118.6± 86.7 mg/day and 1.33±0.64 mg/dl respectively. Neuropathy was reported in 32% patients, 8% had retinopathy whereas 13.33%had cardio vascular disease. Significant positive correlation was observed for duration of diabetes (r=0.43, p<0.05), microalbuminuria (r =0.34, P<0.05 ) and HbA1c (r=0.28, p<0.05) with other micro and macrovascular complications.
Conclusion: Increased HbA1c, longer duration diabetes and increased microalbuminuria level were associated with progression of micro and macrovascular complications in T2DM patients.
Keywords: Microvascular complications, glycosylated haemoglobin, microalbuminuria, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy.
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