Title: Ultrasonographic Evaluation of Foetal Hydronephrosis

Authors: Dr Josey Verghese, Dr Kishore Mandal, Dr Sajitha, K, Dr Suma Job

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i3.171

Abstract

Objectives: Hydronephrosis is commonly detected during routine ultrasound examination of antenatal mothers. There are multiple conflicting prognostic factors in the available literatures with no clear focus on the postnatal outcome. The aim of this study is to assess the outcome of antenatally diagnosed hydronephrosis, based on third trimester antanatal ultrasonography.

Materials and Methods: Based on the third trimester fetal ultrasound findings, patients were divided into group I (unilateral hydronephrosis) and group II (bilateral hydronephrosis, ureteric dilatation, bladder wall thickening etc.). Postnatal evaluation and follow-up was performed following a uniform protocol. The outcomes, spontaneous resolution vs. surgical intervention, were compared between groups.  These two groups were further subdivided into subgroups on the basis of third trimester ultrasoung findings and further analysis of outcome was carried out.

Results: Among a total no of 53 patients in this study group;  group I had 39 patients, 5(13%) required surgery;  group II had 14 patients, 4(28%) required surgery. The difference in outcome between the groups was statistically significant ( p=0.01). Among those with unilateral hydronephrosis, none(0/39) with renal anteroposterior pelvic diameter (APD) <15 mm required surgery, while  2 out of 2 patients(2/2) with fetal APD >30 mm required surgery. In those with APD between 15-30 mm, 3 out of 8 (3/8) required surgery and prolonged follow-up was required to arrive at the decision. The difference in outcome between the subgroups was statistically significant ( p=0.001, Chi-square test). Group II had two subgroups. Subgroup I consisted of patients with APD < 15 mm with or without ureteric dilatation and bladder wall thickening , whereas subgroup II consisted of cases with APD >/= 15 mm with or without ureteric dilatation and bladder wall thickening. Of 10 cases in subgroup I, 1 (1/10) needed surgical intervention and 3 out of 4 cases (3/4) of subgroup II, needed surgery. The difference in outcome between these two groups was statistically significant (p=0.002, Chi-square test).

Conclusions: The results of our study show that simple unilateral fetal hydronephrosis runs a benign course. In the presence of hydronephrosis larger than 15 mm, bilateral disease or ureteric dilatation, detailed postnatal evaluation and regular follow-up is warranted to plan a timely intervention.

Keywords: Hydronephrosis, Antenatal ultrasonography, Anteroposterior pelvic diameter.

References

1.      Mallik M, Watson AR. Antenatally detected urinary tract abnormalities: more detection but less action. Pediatr Nephrol 2008;23:897.

2.      Cohen HL, Cooper J, Eisenberg P, Mandel FS, Gross BR, Goldman MA, et al. Normal length of fetal kidneys: sonographic study in

3.      Pates JA, Dashe JS. Prenatal diagnosis and management of hydronephrosis. Early Hum Dev 2006;82:3. 397 obstetric patients. AJR Am J Roentgenol 1991;157:545.

4.      Coplen DE, Austin PF, Yan Y, Blanco VM, Dicke JM. The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. J Urol 2006;176:724.

5.      Lee RS, Cendron M, Kinnamon DD, Nguyen HT. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta analysis. Pediatrics 2006;118:586.

6.      Calisti A, Perrotta ML, Oriolo L, Ingianna D, Miele V. The risk of associated urological abnormalities in children with pre and postnatal occasional diagnosis of solitary, small or ectopic kidney: is a complete urological screening always necessary? World J Urol 2008.

7.      Signorelli M, Cerri V, Taddei F, Groli C, Bianchi UA. Prenatal diagnosis and management of mild fetal pyelectasis: implications for neonatal outcome and follow-up. Eur J Obstet Gynecol Reprod Biol 2005;118:154.

8.      Kleiner B, Callen PW, Filly RA. Sonographic analysis of the fetus with ureteropelvic junction obstruction. AJR Am J Roentgenol 1987;148:359.

9.      Zerin JM, Ritchey ML, Chang AC. Incidental vesicoureteral reflux in neonates with antenatally detected hydronephrosis and other renal abnormalities. Radiology 1993;187:157.

10.  Matsui F, Shimada K, Matsumoto F, Takano S. Late recurrence o symptomatic hydronephrosis in patients with prenatally detected hydronephrosis and spontaneous improvement. J Urol 2008;180:322

11.  Gatti JM, BroeckerBH, ScherzHC,Perez-BrayfieldMR, KirschAJ. Antenatal hydronephrosis with postnatal resolution: how long are postnatal studies warranted? Urology 2011;57:1178.

12.  Herndon CD, McKenna PH, Kolon TF, Gonzales ET, Baker LA, Docimo SG. A multicenter outcomes analysis of patients with neonatal reflux presenting with prenatal hydronephrosis. J Urol 1999;162:1203.

13.  Baskin LS, Zderic SA, Snyder HM, Duckett JW. Primary dilated megaureter: long-term followup. J Urol 1994;152:618.

14.  Meyer JS, Lebowitz RL. Primary megaureter in infants and children: a review. Urol Radiol 1992;14:296.

15.  Karnak I, Woo LL, Shah SN, Sirajuddin A, Kay R, Ross JH. Prenatally detected ureteropelvic junction obstruction: clinical features and associated urologic abnormalities. Pediatr Surg Int 2008;24:395.

16.  Ross MG, Brace RA. National institute of child health and development conference summary: amniotic fluid biology basic and clinical aspects. J Matern Fetal Med 2001;10:2.

17.  Favre R, Kohler M, Gasser B, Muller F, Nisand I. Early fetal megacystis between 11 and 15 weeks of gestation. Ultrasound Obstet Gynecol 1999;14:402.

18.  Jouannic JM, Hyett JA, Pandya PP, Gulbis B, Rodeck CH, Jauniaux E. Perinatal outcome in fetuses with megacystis in the first half of pregnancy. Prenat Diagn 2003;23:340.

19.  Hulbert WC, Rabinowitz R. Prenatal diagnosis of duplex system hydronephrosis: effect on renal salvage. Urology 1998;51:23.

20.  Grignon A, Filion R, Filiatrault D, Robitaille P, Homsy Y, Boutin H, et al. Urinary tract dilatation in utero: classification and clinical applications. Radiology 1986;160:645.

Corresponding Author

Dr Josey Verghese

Department of Radiodiagnosis, Govt.T.D Medical College, Alappuzha, Kerala, India

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. PH: 9447342889, FAX: 04772282368