Title: Frequency of the ABO and Duffy Phenotypes among Saudi Population in Eastern Provence

Authors: Latefah Almsned, Fahad Almsned

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i3.154

Abstract

Objectives: To document the frequency of the ABO and Duffy blood groups antigens and phenotypes among Saudi population in eastern province.

Methods: Hundred healthy individual adult have participated in this study (50 males, 50 females). Their blood was tested for ABO and for common Duffy antigens by using the tube agglutination method.

Results: The O antigen was the most common antigen among the study group (39%), followed by A (35%), B (18%), and the least common antigen was AB (8%). The most common Duffy antigens were Fya antigen (16%) and also Fyb antigen (16%).  Regarding to Frequency of Duffy phenotypes, the phenotype Fy (a-b-) was the commonest Duffy phenotype (72%), followed by Fy (a+b-) and Fy (a-b+), and Fy (a+b+) was least common (4%).

Conclusion: The O blood group is the most common phenotype in Saudi population, and the AB blood group is the least common phenotype. The phenotypes Fy (a-b-) was found to be of the highest frequency in our study than the other phenotypes. There is no significant difference between males & females of Saudi population in the distribution of ABO & Duffy blood group systems.

References

1.      Landsteiner K: Zur Kenntnis der antiferm-entativen, lytischen und agglutininner-enden Wirkungendes Blutserums und der Lymphe. Zentralbl Bakteriol27 : 357-362, 1900.

2.      Decastello A, SturliA: ”Ueber die Isoagglutinineim Serum gesunder und kranker Menschen”. Mfinch med Wschr49 : 1090-1095, 1902.

3.      Daniels, G. L., Anstee, D. J., Cartron, J. P., Dahr, W., Issitt, P. D., Jorgensen, J., Kornstad, L., Levene, C., Lomas-Francis, C. & Lubenko. (1995). Blood group terminology: ISBT working party on terminology for red cell surface antigens. Vox Sang, 69:265-279.

4.      Racial &Ethnic, Blood bank.Com, Distribution of ABO Blood Types Cited 15th March, 2005.

5.      Ernest Beutler, (2001). William’s Hematology, 6th edn. The Mc Graw,Hill Companies, Sanfrancisco, 2001:1840-53.

6.      Mollison, P. L., Engelfriet, C. P. & Marcelac. (1997). Blood transfusion in clinical medicine. 10th edition, Oxford Blackwell scientific puplications.

7.      Turgeon, ML 1995, Fundamentals of immunohematology: theory and technique, 2nd edn, Williams &Wilkins, Baltimore.

8.      Dean : Laura Dean, M.D ,Blood groups and red cell Antigens ,volume 5,2005.

9.      Hamed CT, Bollahi MA, Abdelhamid I, Med Mahmoud MA, Ba B, Ghaber S, Habti N, Houmeida A. Frequencies and ethnic distribution of ABO and Rh(D) blood groups in Mauritania: results of first nationwide study: 2012, 39, 151–154.

10.  Abdullah SM. Frequency of ABO and Rh blood groups in the Jazan region of Saudi Arabia. Pak J Med Sci 2010; 26(4):818-821.

11.  Bashawri LA, Al-Mulhim AA, Ahmad MS, Ahmed MA. Frequency of ABO blood groups in the Eastern region of Saudi Arabia. Saudi Med J 2001;22 (11):1008-1012.

12.  R.N. Makroo, Aakanksha Bhatia, Richa Gupta & Jessy Phillip. Prevalence of Rh, Duffy, Kell, Kidd & MNSs blood group antigens in the Indian blood donor population. Indian J Med Res 137, March 2013, pp 521-526.

13.  Carlos Cotorruelo. Claudia Biondi .Liliana Racca .Silvia Garcı´aBorra´s Amelia Racca. Duffy genotyping facilitates transfusion therapy. ClinExp Med (2009) 9:249–251.

Corresponding Author

Latefah Almsned

School of Systems Biology, George Mason University, Fairfax, VA 22030

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