Title: Designing Antimicrobial Peptide: Current Status
Author: Fahad Almsned
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.153
Abstract
1. Introduction
Antimicrobial peptides (AMPs) are critical part of the human natural immunity, innate specifically, which is found among all modules of life. These peptides, which are produced by leukocytes, are working as broad-spectrum antibiotics that exhibit potential as novel therapeutic agents. AMPs have been confirmed to eliminate G-ve and G+ve bacteria, enveloped viruses, fungi, and even cancerous cells1. AMPs eliminate these invading objects by direct antimicrobial effect as well as other effects like suppressing bacterial protective biofilm formation and enhancing the bacterial elimination by phagocytosis2. AMPs, comparing to conventional antibiotics, may also have the ability to enhance immunity by functioning as immuno modulator through a variety of actions, like apoptotic control on immune cells, chemokine release by epithelial cells, enhancing wound healing, and many other actions that help promoting adaptive immunity3-4.
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Fahad Almsned
School of Systems Biology, George Mason University, Fairfax, VA 22030
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.